This review (2022) explores the cellular mechanisms involved in MDMA neuroinflammatory effects. The protective effects of adenosine receptors are also discussed.
“3,4-methylenedioxymethamphetamine (MDMA) is a worldwide abused psychostimulant, which has neurotoxic effects on dopaminergic and serotonergic neurons in both rodents and non-human primates. Adenosine acts as a neurotransmitter in the brain through the activation of four specific G-protein-coupled receptors and it acts as a neuromodulator of dopamine neurotransmission. Recent studies suggest that stimulation of adenosine receptors oppose many behavioural effects of methamphetamines. This review summarizes the specific cellular mechanisms involved in MDMA neuroinflammatory effects, along with the protective effects of adenosine receptors.”
Authors: Fatemeh Kermanian, Masoumeh Seghatoleslam & Simin Mahakizadeh
- Adenosine receptors appear to have great potential for treating side effects of MDMA.
- Adenosine receptors could decrease microglial activation in neuroinflammation conditions.
- MDMA and adenosine receptors have opposite effects on dopaminergic and serotonergic systems.
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January 3, 2022