Embracing Neurodiversity in Psychedelic Science: A Mixed-Methods Inquiry into the MDMA Experiences of Autistic Adults

This retrospective survey (n=100) and qualitative interview (n=24) study examined the MDMA experiences of autistic adults and identified that many of them viewed MDMA as a transformative healing catalyst for helping their anxieties of navigating through neurotypical social norms, while none of them expressed the desire for being neurotypical or reported being “cured” from autism.


Introduction: This exploratory inquiry analyzed subjective experiences autistic adults reported after they took the drug 3,4-methylenedioxymethamphetamine (MDMA), also known as ecstasy, in nonclinical settings.

Methods: Using a secure, globally available website, this study collected data from participants in 13 countries who were experienced with MDMA (n = 100). A subset of survey respondents (n = 24) were then invited to participate in qualitative interviews. The researcher applied thematic content analysis of interview transcripts to create a comprehensive account of emergent themes.

Results: MDMA has well-documented acute effects that promote pro-social attitudes such as caring and trust in neurotypical, or typically developing, populations. Findings from this study suggested that MDMA-assisted therapy may be an effective catalyst in autistic adults for intra- and interpersonal change. In addition, participants reported accounts of lasting transformation and healing from conditions such as trauma and social anxiety that are common in autistic populations. No participants reported long-term adverse outcomes as a result of using MDMA/ecstasy.

Discussion: Qualitative findings support a case for future clinical trials of MDMA-assisted therapy with autistic adults who present with social adaptability challenges.

Authors: Alicia L. Danforth

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Study details

Compounds studied

Topics studied
Anxiety Autism

Study characteristics
Survey Interviews Qualitative



Authors associated with this publication with profiles on Blossom

Alicia Danforth
Alicia Danforth is a clinical psychologist who specializes in psychotherapy for autistic adults (private practice). Next to this she also works on several clinical studies and provides integration work.

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