Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review

This systematic review (2018) examines the efficacy of ketamine treatment for substance use disorder and summarizes evidence which suggests that ketamine may improve the ability to establish and maintain abstinence.

Abstract

Background:ย Despite advances in behavioral and pharmacotherapy interventions, substance use disorders (SUDs) are frequently refractory to treatment. Glutamatergic dysregulation has received increasing attention as one common neuropathology across multiple substances of abuse. Ketamine is a potent N-methyl-D-aspartate (NMDA) glutamatergic receptor antagonist which has been found to be effective in the treatment of severe depression. Here we review the literature on the efficacy of ketamine in the treatment of SUDs.

Methods: A systematic review of the PubMed, Scopus, and ClinicalTrials.gov databases was undertaken to identify completed and ongoing human studies of the effectiveness of ketamine in the treatment of SUDs between January 1997 and January 2018.

Results: Seven completed studies were identified. Two studies focused on alcohol use disorder, two focused on cocaine use disorder, and three focused on opioid use disorder. Both cocaine studies found improvements in craving, motivation, and decreased cocaine use rates, although studies were limited by small sample sizes, a homogeneous population and short follow-up. Studies of alcohol and opioid use disorders found improvement in abstinence rates in the ketamine group, with significant between-group effects noted for up to two years following a single infusion, although these were not placebo-controlled trials.

Conclusion: These results suggest that ketamine may facilitate abstinence across multiple substances of abuse and warrants broader investigation in addiction treatment. We conclude with an overview of the six ongoing studies of ketamine in the treatment of alcohol, cocaine, cannabis, and opioid use disorders and discuss future directions in this emerging area of research.”

Authors: Jennifer L. Jones, Camilo F. Mateus, Robert J. Malcolm, Kathleen T. Brady & Sudie E. Back

Become a psychedelic insider!

With a free Blossom membership you will always be in the know.

๐Ÿ“ฐ Weekly newsletter about the psychedelic research

โœ”๏ธ Unlimited access to our database and original articles

๐Ÿ–Š๏ธ Add (private) notes and comments to each page

Make an account
0 Comments
Inline Feedbacks
View all comments
0
Would love your thoughts, please comment.x
()
x