This hypothesis article (2022) argues that psychedelics may be helpful in long-duration space travel. This is argued from several lines of thought, including 1) neuroplasticity, 2) wellness, and 3) support cognition, empathy, and transcendence.
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A long trip into the universe: Psychedelics and space travel
https://doi.org/10.3389/frspt.2022.899159
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