Database

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This double-blind, randomized, controlled cross-over study (n=13) explores MDMA's (30-70mg) impact on tinnitus through behavioural and rs-fMRI assessments. No notable effects were observed at the lower dose. However, the 70 mg dose significantly reduced tinnitus annoyance and ignore ratings post-administration. Neurophysiological analysis revealed decreased connectivity in emotion and memory-related brain regions (hippocampal and amygdala) and increased connectivity in sensory processing and attention areas (right post-central gyrus, posterior and superior temporal gyrus, thalamus, and frontoparietal network) with MDMA versus placebo.
Category: Papers
Published: 2024-02-23
This open-label trial (n=15) will investigate the efficacy and feasibility of psilocybin-assisted psychotherapy for treatment-resistant depression (TRD).
Category: Trials
Published: 2024-02-23
This open-label pilot study (n=5) aims to assess the feasibility of a single microdose of ayahuasca alkaloids (30mg) on neurotransmitter and inflammation marker levels, safety observations, and mood self-efficacy in healthy adults.
Category: Trials
Published: 2024-02-23
This double-blind, placebo-controlled Phase II pilot study (n=14) investigates the safety and efficacy of MDMA-assisted manualised psychotherapy (30-125mg) in Australian war veterans with chronic, treatment-resistant posttraumatic stress disorder (PTSD).
Category: Trials
Published: 2024-02-23
This randomised controlled trial (n=30) investigates the antidepressant effects of intravenous ketamine (35mg/70kg; 2x) as an add-on therapy for patients with major depressive disorder (MDD).
Category: Trials
Published: 2024-02-23
The University of Auckland is engaged in research on the therapeutic uses of psychedelic drugs, focusing on substances like LSD, ketamine, and MDMA to address mental health issues.
Category: Companies
Published: 2024-02-23
This placebo-controlled, double-blind crossover trial (n=40) explores the potential therapeutic effects of a low dose (30-70mg) of MDMA for treating tinnitus.
Category: Trials
Published: 2024-02-23
How can microdosing support people who experience ADHD, and does it work better than conventional medications? The first article explores this across two studies. We then venture into the heart of Europe, where psychedelic-assisted psychotherapy has been legally possible for the last decade (again). Finally, I'll focus on the flexible repeated dosing in a trial with psilocybin for depression.
Category: Briefings
Published: 2024-02-21
This open-label waitlist trial (n=30) assessed the feasibility of psilocybin-assisted psychotherapy (PAP/PAT) in a complex population with treatment-resistant depression (TRD), including major depressive and bipolar II disorders, baseline suicidality, and significant comorbidity. Participants received one, two, or three sessions of PAP with psilocybin (25mg), accompanied by preparation and integration psychotherapy sessions. Immediate treatment showed greater reductions in depression severity (MADRS) compared to the waitlist period, with a large effect size (g = 1.07, p < 0.01). Repeated doses were associated with further reductions in depression severity. Adverse events were transient, and the study demonstrated feasibility, preliminary antidepressant efficacy, safety, and tolerability in this population.
Category: Papers
Published: 2024-02-21
This prospective survey (n=233, 64, 44) explores microdosing's (MD) impact on emotional regulation (ER) and empathy in adults with severe ADHD symptoms. Positive effects on ER and empathy were observed, specifically in cognitive reappraisal, expressive suppression, perspective-taking, and personal distress. However, a comparison with those using only conventional medications (n=180, 50, 38 MD; n=37, 27, 28 conventional) revealed that after four weeks, only expressive suppression improvement persisted, and cognitive reappraisal and empathy enhancements disappeared.
Category: Papers
Published: 2024-02-21

Psychedelic Database

Find everything on psychedelics as medicine. This page allows you to search through our whole database, from research papers to news articles, and from clinical trials to academic articles.

Next to our databases, don’t forget to check out our reports. The reports bring together the separate pieces of information from our database entries into written reports.