Database

This balanced-order crossover study (n=20) investigates the effects of LSD (75µg) on the pain neural network using fMRI in healthy subjects. The study finds that LSD modulates brain regions involved in pain processing, showing differences in activity and connectivity compared to placebo, and highlights potential implications for future cognitive science and pharmacology research.

This prospective longitudinal survey (n=8) focused on Canadians with Section 56 exemptions for legal psilocybin-assisted psychotherapy. Participants (Mage=52.3, all with cancer) showed significant improvements in anxiety, depression, pain, fear of COVID-19, quality of life, and spiritual well-being two weeks post-treatment. Most found the sessions meaningful but challenging, with one reporting decreased well-being.

This placebo-controlled study (n=53) investigates the effects of repeated low doses of LSD (15μg; 4x) on arousal, attention, and memory. LSD produces stimulatory effects, reducing EEG delta, theta, and alpha power, and enhancing pre-attentive processing, with the strongest effects in individuals with low baseline arousal. Inhibitory effects were observed in high-memory performers. The effects persisted during a 1-week follow-up, suggesting sustained neuroadaptations.

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This in vitro study investigates the receptor binding profiles of NBOMe drugs compared to their 2C drug analogs and LSD. It finds that NBOMe drugs exhibit high affinity for 5-HT2A receptors, suggesting strong hallucinogenic effects similar to LSD, but with potentially more stimulant properties due to interactions with α1 receptors.

This in vitro study examines 2,5-dimethoxy-4-substituted phenethylamines (PEAs) including 2C-I, 2C-B, 2C-D, and 2C-H analogs, focusing on their receptor interactions. It finds these compounds act as 5-HT2A receptor antagonists, differing in potency based on specific substituents. This suggests their psychostimulant effects may not solely derive from 5-HT2A receptor agonism.

This within-subject MRI study (n=11) finds that inhaled DMT increases the mean population receptive field (pRF) sizes in the peripheral visual field of the primary visual cortex (V1). Documented by the Hallucinogen Rating Scale (HRS), this effect explains visual perceptual distortions like field blurring and tunnel vision, and supports the role of 5-HT2A receptor activation in controlling visual cortex activity.

This secondary analysis from a DMT study explores the impact of intentional cognitive interruptions on psychedelic experiences. The study investigates whether increasing cognitive load during the experience affects subjective ratings, hypothesizing that higher task demands would lower these ratings. Additionally, it examines whether reduced task demands correlate with larger reductions in long-term depressive symptoms.

This experimental study investigates the behavioral, neurochemical, and EEG profiles 2C-B in rats. 2C-B demonstrates biphasic effects on locomotion, initially inhibitory and then excitatory, contrasting with amphetamine which induces solely hyperlocomotion. Both compounds disrupt prepulse inhibition (PPI) of the startle reaction, albeit with different effects on acoustic startle response (ASR). In the nucleus accumbens (NAc), 2C-B increases dopamine levels but decreases 3,4-dihydroxyphenylacetic acid (DOPAC), suggesting potential psychotomimetic and addictive properties. EEG analyses reveal that low doses of 2C-B reduce power spectra and coherence, whereas high doses show biphasic effects on EEG power and coherence.