This comprehensive review (2022) explores the positive and negative aspects of different formulations and routes of administration of DMT. Alternative routes to oral administration in tandem with a monoamine oxidase inhibitor (ayahuasca/pharmahuasca) are discussed as well as the role of endogenous DMT in normal brain function.
Abstract
“As with all drugs, the route, form, and/or dose of a substance administered or applied can play a defining role in its overall pharmacology and use as a therapeutic. This review will focus on these factors as they relate to the psychedelic N,N-dimethyltryptamine (DMT). It will examine the positive and negative aspects of different formulations and routes of administration of DMT and the observed effects from such administrations in the form of ayahuasca teas; oral “pharmahuasca”; injections by intravenous (IV) and intramuscular (IM) routes; inhalation, insufflation; and other routes; and high-dose, low-dose, and “micro-dose” effects. The review will consider the possible oral route of administration alternatives that would not require concomitant use of a monoamine oxidase inhibitor. The review will then address the current research findings for DMT from in vivo and in vitro studies as well as the possibility that these findings may be revealing the role of endogenous DMT in normal brain function.”
Authors: Steven A. Barker
Summary of Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT
Introduction
Psychedelics have shown great promise for the treatment of depression, post-traumatic stress disorders, substance abuse and addiction, as well as many other maladies. They also have neuroplastogenic effects, such as reducing infarct size and enhancing functional recovery following brain ischemia.
As with all drugs, the route, form, and dose of a substance administered or applied can play a defining role in its overall pharmacology and use as a therapeutic. This review will focus on the positive and negative aspects of different formulations and routes of administration of DMT.
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https://doi.org/10.1007/s00213-022-06065-0
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