Prophylactic Effects of Psilocybin on Chronic Cluster Headache

This study aims to investigate the prophylactic effects of psilocybin in chronic cluster headaches. Subjects will receive a low dose of psilocybin during three sessions spaced over one week. Subjects will maintain a headache diary prior to, during, and after the administrations to document headache frequency, intensity and duration. Subjects will undergo an fMRI scanning before the first and after the last psilocybin session.

This trial was terminated because of covid, but 10 patients had gone through the study protocol, and the accompanying paper is the result of this work.

Topic Pain Headache Disorders
Compound Psilocybin
Country Denmark
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Trial Details



Trial Number

Sponsors & Collaborators

Copenhagen University Hospital Rigshospitalet
The university hospital in Copenhagen, the Rigshospitalet, is Denmark's most prestigious (and largest) hospital. Literally translated, the name stands for 'Hospital of the Realm.' Researchers here are working on at least three psychedelic trials with psilocybin.

Papers

CCH attack frequency reduction after psilocybin correlates with hypothalamic functional connectivity
This open-label study (n=10) finds that three moderate doses of psilocybin (10mg/70kg) significantly reduced the frequency of chronic cluster headaches (CCH). On average, the frequency was reduced by 30%. One participant was free from CCHs for 21 weeks.

Data attribution

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