Long-lasting analgesic effect of the psychedelic drug changa: A case report

This case study (n=1) describes the analgesic effects of repeated changa (unspecified amount of DMT) treatment administered to a 57-year-old male doctor who was suffering for 10 years from chronic fatigue and persistent pain due to fibromyalgia.

Abstract of Long-lasting analgesic effect of the psychedelic drug changa

“Background and aims: Pain is the most prevalent symptom of a health condition, and it is inappropriately treated in many cases. Here, we present a case report in which we observe a long-lasting analgesic effect produced by changa, a psychedelic drug that contains the psychoactive N,N-dimethyltryptamine and ground seeds of Peganum harmala, which are rich in β-carbolines.

Methods: We describe the case and offer a brief review of supportive findings.

Results: A long-lasting analgesic effect after the use of changa was reported. Possible analgesic mechanisms are discussed. We suggest that both pharmacological and non-pharmacological factors could be involved.

Conclusion: These findings offer preliminary evidence of the analgesic effect of changa, but due to its complex pharmacological actions, involving many neurotransmitter systems, further research is needed in order to establish the specific mechanisms at work.“

Authors: Genís Ona & Sebastián Troncoso

Summary of Long-lasting analgesic effect of the psychedelic drug changa