Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder

This pilot study (n=8) aims to assess the feasibility of using ketamine-assisted treatment for tobacco use disorder, alongside brief motivational enhancement therapy.

Conducted by the Medical University of South Carolina, participants aged 21 to 65, who are daily cigarette smokers with multiple unsuccessful quit attempts, will receive weekly ketamine sessions for three weeks.

The primary outcome will be the feasibility of completing the full treatment. Secondary outcomes include measuring smoking cessation and reduction in cigarettes smoked per day using saliva cotinine levels and self-reported timeline follow-back, respectively. Recruitment for the study is ongoing, with an estimated completion date of May 2024.

Topic Smoking Addiction
Compound Ketamine Placebo
Country United States of America
Visit trial
Status Recruiting
Results Published No
Start date 02 May 2023
End date 31 May 2024
Phase Phase I
Design Open
Type Interventional
Generation First
Participants 8
Sex All
Age 21- 65
Therapy Yes

Trial Details

The purpose of the study is to examine whether an investigational medication called ketamine is able to improve treatment outcomes for tobacco use disorder when delivered in conjunction with brief motivational enhancement therapy. Participants will receive ketamine assisted motivational enhancement therapy weekly for three weeks and there will be 2 follow up visits. All visits will also consist of questionnaires and saliva samples will be taken. The overall participation will last approximately 8 weeks.

NCT Number NCT05796791

Sponsors & Collaborators

Medical University of South Carolina
The Medical University of South Carolina (MUSC) partnered with MAPS to create a psychedelic research centre to study the therapeutic effects of psychedelic drugs on mental illness.

Data attribution

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