Intravenous Esketamine on Prevention of Postoperative Depression in Patients Undergoing Cardiac Surgery

This prevention trial (n=80) will assess the effect of a subanaesthetic dose of esketamine on preventing postoperative depression in patients undergoing cardiac surgery.

Esketamine, known for its antidepressant effects, will be intravenously infused before anaesthesia induction. The study aims to determine if this intervention can prevent or mitigate postoperative depressive symptoms common in cardiac surgery patients.

The trial, conducted by Anshi Wu at Beijing Chao Yang Hospital, Capital Medical University, involves patients aged 18 and above with moderate to severe depressive symptoms scheduled for heart surgery. The primary completion date was in December 2021, with the study estimated to be completed by December 2022.

It is a randomised, double-blind, placebo-controlled pilot and feasibility trial, with primary outcome measures including response rate and secondary measures such as anxiety symptoms, postoperative delirium, and quality of life.

Topic Depression
Compound Ketamine Placebo
Country China
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