Effect of Low-dose Esketamine on Postoperative Depression in Patients With Breast Cancer

Esketamine is an optical isomer of ketamine. Compared with ketamine, esketamine has the characteristics of higher effective value, stronger receptor affinity, less adverse reactions of nervous system, and pharmacokinetics is controllable.

Domestic and foreign studies have focused on the therapeutic effect of esketamine on major depression, but less attention has been paid to perioperative depression.

This study intends to explore the effect of small doses of esketamine on patients with breast cancer.Postoperative depression and pain are observed.

Topic Depression Pain
Compound Placebo Ketamine
Country China
Visit trial
Status Recruiting
Results Published No
Start date 10 February 2021
End date 10 May 2022
Chance of happening 100%
Phase Not Applicable
Design Blinded
Type Interventional
Generation First
Participants 180
Sex All
Age 18- 63
Therapy No

Trial Details

This study intends to explore the effect of small doses of esketamine on patients with breast cancer.WE pay attention to : Safety of low-dose single intravenous injection of esketamine (1) The influence of intraoperative vital signs of patients after medication, such as blood pressure and heart rate fluctuation; (2) the duration of recovery after anesthesia; (3) postoperative adverse reactions, such as nausea and vomiting, dizziness and diplopia, respiratory depression, laryngeal spasm, delirium agitation, etc 2. Effect of single intravenous injection of low-dose ketamine on postoperative depression in patients undergoing radical mastectomy (1) 1 day before surgery, 2 days, 5 days, 30 days, 90 days after surgery Hamilton Depression Scale scores; (2) The serum leptin level 1 day before surgery, 2 days after surgery and 5 days after surgery; (3) Correlation between depression scale score and leptin level Effects of low dose esketamine on acute and chronic pain in patients undergoing radical mastectomy; - visual analogue scale scores at 6, 12 and 24 hours after surgery; - visual analogue scale scores at 3, 5, 30 and 90 days after surgery; - the number of analgesic remedies

NCT Number NCT04850937

Sponsors & Collaborators

Yangzhou University
Yangzhou University is one of the few locations in China where research with psychedelics is taking place.

Data attribution

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