Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects (2C-B)

This RCT (n=24) does a direct comparison, the first one in a double-blind trial, of MDMA, psilocybin, and 2C-B (a novel psychedelic with MDMA & psilocybin-like effects). Next to a placebo, the dosages of MDMA (125mg) and psilocybin (25mg) are high, whilst that of 2C-B will be a variety of doses (10, 20, 30mg). All participants will receive all compounds and a placebo (cross-over study design).

Topic Healthy Subjects
Compound MDMA 2C-X Psilocybin
Country Switzerland
Visit trial
Status Not yet recruiting
Results Published
Start date 31 December 2022
End date 31 March 2024
Phase Phase I
Design Blinded
Type Interventional
Generation First
Participants 24
Sex All
Age 25- 65
Therapy No

Trial Details

2-bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive substance with reportedly similar acute effects to both the prototypical empathogen 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and the classic psychedelic substance psilocybin (contained in "magic, hallucinogenic mushrooms"). Pharmacologically, MDMA mainly releases serotonin (5-HT) via the serotonin transporter (SERT) and psilocybin mainly acts as direct agonist at 5-HT2A receptors. 2C-B interacts with both the 5-HT2A receptor and SERT which is in line with its reported mixed effects profile. However, scientific studies are lacking. There is an increased interest in psychiatric research on the therapeutic properties of MDMA and psilocybin and also on mixed empathogenic-psychedelic substances.

Trial Number NCT05523401

Sponsors & Collaborators

University of Basel
The University of Basel Department of Biomedicine hosts the Liechti Lab research group, headed by Matthias Liechti.

Data attribution

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