Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study) (DMT BDR)

This open-label trial (n=36) will test a variety of mixed (or escalation) doses of DMT (5-25mg) in healthy subjects. The study is unique in testing many different dosages within the same subject (versus between groups).

Topic Healthy Subjects
Compound DMT
Country Switzerland
Visit trial
Status Not yet recruiting
Results Published No
Start date 15 March 2023
End date 30 December 2023
Chance of happening 100%
Phase Phase I
Design Open
Type Interventional
Generation First
Participants 36
Sex All
Age 25- 65
Therapy No

Trial Details

N,N-dimethyltryptamine (DMT) is a naturally-occurring psychedelic substance widely used in recreational and spiritual settings (Ayahuasca). DMT is considered a tool to induce an altered state of consciousness of interest in psychological and psychiatric research. DMT is rapidly metabolized by monoamine oxidase (MAO) A. Therefore, it is inactive when administered orally and has a very short duration of action when administered parenterally (<20 min). However, to date no clinical study has investigated dose-response effects over a broad range of different doses of DMT within the same patient. The aim of the present study is to experimentally test different intravenous DMT bolus doses over a broad dose range and investigate the related subjective and autonomic effects in order to establish a precise dose-response relationship of DMT in healthy subjects.

NCT Number NCT05695495

Sponsors & Collaborators

University of Basel
The University of Basel Department of Biomedicine hosts the Liechti Lab research group, headed by Matthias Liechti.

Data attribution

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