2C-B vs psilocybin Maastricht Study

This trial is registered with the Dutch trial registry that has been offline for over a year and hasn’t been registered in any other database. We will update this record once it becomes available. All data are estimates.

Topic Healthy Subjects
Compound Psilocybin 2C-X
Country Netherlands
Visit trial
Status Completed
Results Published Yes
Start date 01 January 2022
End date 01 January 2023
Chance of happening 100%
Phase Not Applicable
Design Open
Type Interventional
Generation First
Participants 22
Sex All
Age 18- 65
Therapy No

Trial Details

This trial is registered with the Dutch trial registry that has been offline for over a year and hasn't been registered in any other database. We will update this record once it becomes available.

NCT Number NL8813

Sponsors & Collaborators

Maastricht University
Maastricht University is host to the psychopharmacology department (Psychopharmacology in Maastricht) where various researchers are investigating the effects of psychedelics.

Papers

Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition
This double-blind study (n=22) compares the effect of 2C-B (20mg) and psilocybin (15mg). It finds that 2C-B elicited alterations in consciousness of a psychedelic nature but with a shorter duration of self-reported effects than psilocybin. The study categorised 2C-B (at least at that dose) as a subjectively "lighter" psychedelic.

Psilocybin and 4-Bromo-2,5-Dimethoxyphenethylamine (2C-B) at Encoding Distort Episodic Familiarity
This re-analysis of an RCT study (n=20) tested the acute effects of psilocybin and 2C-B on the encoding of emotional episodic memories. The study finds that both psychedelics impair estimates of recollection and familiarity, increase familiarity-based false alarms for emotional stimuli, and affect metamemory, indicating a common neurocognitive mechanism across these drugs.

Data attribution

A large set of the trials in our database are sourced from ClinicalTrials.gov (CTG). We have modified these post to display the information in a more clear format or to correct spelling mistakes. Our database in actively updated and may show a different status (e.g. completed) if we have knowledge of this update (e.g. a published paper on the study) which isn't reflected yet on CTG. If a trial is not sourced from CTG, this is indicated on this page and you can follow the link to the alternative source of information.