Psychedelic Research Links April 2022

This is all the other psychedelic research that comes out in April 2022. These papers don’t (yet) have their own page in our database.

This page will be updated (almost) every day.

You can find all interesting papers in our Papers Database.

Related Papers

Use CTRL/CMD+F to quickly search if anything relevant for you has been published this month.

• New Insights into the Chemical Composition of Ayahuasca (chemistry, quantitative and qualitative analysis of ayahuasca alkaloids)
• The effect of 3,4-methylenedioxymethamphetamine (MDMA) on human genetic material: an in vitro study (“the in vitro effect of MDMA on human genetic material, by estimating sensitive cytogenetic indices“)
• NBOMe Toxicity and Fatalities: A Review of the Literature (review)
• Loss of Consciousness and Visual Hallucinations Related to 5-MeO-DALT Intake, a Case Report Confirmed by Toxicological Analyses (case study)
• Pharmacological characterization of 3,4-methylenedioxamphetamine (MDA) analogues and two amphetamine-based compounds: N,α-DEPEA and DPIA (characterization of MDA analogues)
• Ritual drug use during Inca human sacrifices on Ampato mountain (Peru): Results of a toxicological analysis (“the results of toxicological studies of two individuals immolated over 500 years ago during a capacocha ritual“)
• Validation and exploratory application of a simple, rapid and economical procedure (MESQ) for the quantification of mescaline in fresh cactus tissue and aqueous cactus extracts (method for quantifying mescaline concentration in cacti)
• Effects of repeated ayahuasca administration on behaviour and c-Fos expression in male rats exposed to the open field (exploring the effects ayahuasca has on the genetic material in rats)
• Drug and MDMA Interactions Implications for Public Health (book chapter)
• Brain Changes Associated With Long-Term Ketamine Abuse, A Systematic Review (“Given the effect that long-term ketamine exposure may yield, an effort should be made to curb its abuse“)
• Effect of LSD and music on the time-varying brain dynamics (neuroimaging study, “music, as a crucial element of setting, can potentially have an influence on the subject resting-state“)
• Validation of a French Version of the Mystical Experience Questionnaire with Retrospective Reports of the Most Significant Psychedelic Experience among French Users (“this work aimed at validating a French version of a tool used to measure mystical experiences: the Revised Mystical Experience Questionnaire-30 items (MEQ30)”)
• “Selective” serotonin 5-HT_2A receptor antagonists (review, “the limitations and strengths of currently available “selective” 5-HT_2AR antagonists“)
• Combining FTIR-ATR and OPLS-DA methods for magic mushrooms discrimination (chemistry, a method to screen mushrooms species)
• Monoamine oxidase inhibition by plant-derived β-carbolines; implications for the psychopharmacology of tobacco and ayahuasca (“the preclinical and clinical observations with synthetic MAO inhibitors present a background for obtaining a better understanding of the polypharmacologies of tobacco and ayahuasca“)
• An overview of the taxonomy, phylogenetics and ecology of the psychedelic genera Psilocybe, Panaeolus, Pluteus and Gymnopilus (review, “species identification, taxonomy and classification, available DNA sequence data and psychedelic species”)
• Can the revival of serotonergic psychedelic drugs as treatments for mental disorders help to characterize their risks and benefits? (commentary)
• Charismatic, Synchronous and Psychedelic Religious Experiences: A Personal Account (case study)
• Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms (0.2% of magic mushroom users on the Global Drug Survey 2017 reported visiting the emergency room)
• Neuroimaging Documentation of Psychedelic Drugs Effect on the Brain: DMT, LSD, Psilocybin, and Ibogaine as Examples: A Mini Review (review)
• Automated Computer Software Assessment of 5-Hydroxytryptamine 2A Receptor-Mediated Head Twitch Responses from Video Recordings of Mice (“we validated a simple non-invasive method for quantitating HTRs using computer-based analysis of experimental video recordings“)
• Quantum Chemical Study of the Hydrolysis of Oxidized Endogenous Psychedelic N,N-Dimethyltryptamine (chemistry)
• Components of Banisteriopsis caapi, a Plant Used in the Preparation of the Psychoactive Ayahuasca, Induce Anti-Inflammatory Effects in Microglial Cells (in vitro study)
• On the degrees of freedom worth having: psychedelics as means of understanding and expanding free will (theory-building, how various mechanisms of free will may overlap with serotonergic signalling pathways that mediate the effects of psychedelics)
• The Influence of Recreational Drug Use on Experiences of the Passage of Time (“whilst distortions to the passage of time are a common feature of drug use, their causes are complex“)
• Manifest Your Desires: Psychedelics and the Self-Help Industry (“we draw on some critiques of the self-help industry to propose potential parallels in the psychedelic industry”)
• Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine (“Ecstasy”) induced cytoskeletal damage (cells, “a differentiated 5-HT neuronal cell line obtained from rat raphe nucleus (RN46A) was treated in vitro with either MDMA, BDNF, MDMA + BDNF, or vehicle”)
• Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety Disorders (review)
• Long-term safety of ketamine and esketamine in treatment of depression (a safety review of ketamine and esketamine)
• High-sensitivity method for the determination of LSD and 2-oxo-3-hydroxy-LSD in oral fluid by liquid chromatography-tandem mass spectrometry (method for analysing LSD)
• New Pathways for Assisted Psychotherapy: Do Psychedelics Bring Panic or Panacea? (review)
• Pathological Delta Oscillations in Hallucinogen Persisting Perception Disorder: A Case Report (case study)
• Esketamine inhaled as dry powder: Pharmacokinetic, pharmacodynamic and safety assessment in a preclinical study (inhalation as a method of delivering ketamine)
• Safety issues of psilocybin and LSD as potential rapid-acting antidepressants and potential challenges (safety concerns with LSD and psilocybin research)
• Amanita muscaria: Fly Agaric history, mythology and pharmacology (review)
• Self and Knowledge in Psychedelic Therapy: Reply to Commentaries on Philosophy of Psychedelics (commentary)
• How Level is the ‘Cognitive Playing Field’? Context Shapes Alterations in Self-Conception During the Psychedelic Experience (commentary, “the role contextual factors (‘set’ and ‘setting’) play in Letheby’s two-factor account of psychedelic therapy“)
• Through the Psychedelic Looking-Glass: The Importance of Phenomenal Transparency in Psychedelic Transformation (commentary, “the role that attention-related phenomenological changes play in psychedelic transformation and psychotherapy” in Letheby’s Philosophy of Psychedelics)
• Positive Affect and Letheby’s Naturalization of Psychedelic Therapy (commentary, “Letheby’s reliance on a particular conceptualization of ego dissolution experiences is in need of further explanation and justification“)
• Psychedelics Favour Understanding Rather Than Knowledge (commentary, “I want to build on the distinction between processes of discovery and processes of justification to criticise some aspects of Letheby’s epistemology of psychedelics“)
• Serotonin, Predictive Processing and Psychedelics (commentary)
• Belief Now, True Belief Later: The Epistemic Advantage of Self-Related Insights in Psychedelic-Assisted Therapy (commentary)
• The Agency-First Epistemology of Psychedelics (commentary)
• Introduction: Psychedelic Science Needs Philosophy (commentary)
• Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Ayahuasca Use in a Satanic Ritual: A Case Report (“this case report suggests that Ayahuasca could be a potential cause of hypoosmolar hyponatremia secondary to SIADH“)
• Effect of -NBOMe Compounds on Sensorimotor, Motor, and Prepulse Inhibition Responses in Mice in Comparison With the 2C Analogs and Lysergic Acid Diethylamide: From Preclinical Evidence to Forensic Implication in Driving Under the Influence of Drugs (rodent study, “systemic administration of -NBOMe, 2C compounds analogues, and LSD (0.001–10 mg/kg) differently impaired the sensorimotor, reaction time, motor, and PPI responses in mice“)
• Ketamine sex- and dose-dependently mitigates behavioural sequelae induced by a predator-based psychosocial stress model of post-traumatic stress disorder (rodent study, “ketamine can prophylactically prevent the onset of PTSD-like behaviours in males and females“)
• “Selective” serotonin 5-HT_2A receptor antagonists (review, “the limitations and strengths of currently available “selective” 5-HT_2AR antagonists“)
• Effects of a psychedelic 5-HT2A receptor agonist on anxiety-related behaviour and fear processing in mice (“activation of 5-HT2A receptors in the amygdala suppresses fear expression but provide no evidence for an effect on retention of fear extinction“)
• Psilocybin Conspectus: Status, Production Methods, and Considerations (review)
• Psychedelic Mystical Experience: A New Agenda for Theology (review)
• Will psilocybin lose its magic in the clinical setting? (review)
• Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms (“we investigated whether postnatal ketamine administration might induce behavioural features able to mimic ASD typical symptoms in adult mice“)
• Is PTSD an Evolutionary Survival Adaptation Initiated by Unrestrained Cytokine Signaling and Maintained by Epigenetic Change? (review)
• Therapeutic Properties of Ayahuasca Components in Ischemia/Reperfusion Injury of the Eye (rodent study)
• Classical hallucinogens as antidepressant drugs: A cautionary approach (editorial)
• Preliminary results on the long-term effects of dextromethorphan on MDMA-mediated serotonergic deficiency and volumetric changes in primates based on 4-[18F]-ADAM PET/MRI (“this study aimed to evaluate the long-term neurotoxicity of MDMA after 66 months abstinence and explored whether Dextromethorphan could attenuate MDMA-induced neurotoxicity“) 
• Physical Disability and Psychedelic Therapies: An Agenda for Inclusive Research and Practice (commentary, “how psychedelic research and therapies can be made accessible to members of disability communities who might benefit“)
• Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation (review, “…propose that many of these new therapeutic strategies produce benefits through the effect on fear memory“)
• Toward Risk-Benefit Assessments in Psychedelic- and MDMA-Assisted Therapies (viewpoint)
• Clinical Social Workers and Psychedelic-Assisted Therapies: A Qualitative Study on Knowledge, Attitudes, and Professional Response (thesis)
• Vital Sign Changes During Intravenous Ketamine Infusions for Depression: An Exploratory Study of Prognostic Indications (post-hoc analysis, “Physiologic sensitivity to the effects of ketamine may predict treatment responsiveness.“)
• Assessment of Bioactivity-Modulating Pseudo-Ring Formation in Psilocin and Related Tryptamines (chemistry)
• Skepticism About Recent Evidence that Psilocybin Opens Depressed Minds (response to a recent paper critiquing their findings)