Ketamine as an Adjunctive Therapy for Major Depression (KARMA-dep)

Randomised, controlled, parallel-group, pilot clinical trial of ketamine vs. midazolam as adjunctive therapy for depression. The main purpose of the pilot study is to assess trial processes to help inform a future definitive trial.

Topic Depression
Compound Ketamine
Country Ireland
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Trial Details



Trial Number

Sponsors & Collaborators

St Patrick's Hospital
St Patrick's University Hospital is a psychiatric hospital affiliated with Trinity College Dublin.

Papers

Ketamine as an adjunctive therapy for major depression - a randomised controlled pragmatic pilot trial (Karma-Dep Trial)
This trial (n=25) compared the effects of ketamine infusion (n=13, 35mg/70kg) to midazolam (n=12, 3.1mg/70kg) administered once-weekly to people experiencing a depressive episode. There were no major differences between groups as measured using the Hamilton Rating Scale for Depression (HRSD-24).

Data attribution

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