Exploratory Study of Low Dose Psilocybin

The purpose of the present study is to evaluate the feasibility, initial signals of efficacy, and potential mechanisms of action of “microdoses” of psilocybin (i.e., low doses of psilocybin that are not believed to produce mystical-type, transcendent, hallucinogenic, or other overtly salient subjective effects that limit functionality) in the treatment of moderate to severe demoralization (feelings of hopelessness and meaningless that frequently accompany medical illness and other life hardship).

Topic Microdosing Palliative Care
Compound Psilocybin Placebo
Country United States of America
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Trial Details



Trial Number

Sponsors & Collaborators

University of Alabama
Researchers at the University of Alabama are investigating the potential use of psychedelics in a number of disorders.

Diamond Therapeutics
We're creating safe, FDA, EMA and Health Canada supported treatments for neuropsychiatric conditions

Measures Used

Mystical Experience Questionnaire
The MEQ is a self-report measure that has been used to measure mystical-type experiences in laboratory studies of psychedelics. The scale was developed by Walter Pahnke in 1963 and covers the major dimensions of classic mystical experience: unity (internal and external), transcendence of time and space, noetic quality, sacredness, positive mood, and ineffability/paradoxicality. Variations of the MEQ exist; the MEQ-30 and the MEQ-43.

Data attribution

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