Effect of Esketamine on Conscious State in Patients With pDoC

This interventional trial (n=116) will investigate the effect of intraoperative infusion of a subanesthetic dose of esketamine on conscious status in patients with prolonged disorders of consciousness (pDoC) under sevoflurane anaesthesia.

The study, led by Dr. Ruquan Han at Beijing Tiantan Hospital, aims to understand the impact of esketamine on conscious states in patients with pDoC undergoing surgery. Participants aged 16 to 65 and experiencing pDoC after acquired brain injury will receive either esketamine or normal saline intravenously during surgery.

Outcome measures include assessing consciousness using the Coma Recovery Scale-Revised (CRS-R), Glasgow Coma Scale (GCS), Full Outline of UnResponsiveness (FOUR) scores, SedLine multi-channel electroencephalogram, and perioperative adverse events. The trial is estimated to begin in May 2024 and complete by June 30, 2026.

Topic Traumatic Brain Injury
Compound Ketamine Placebo
Country China
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Beijing TianTan Hospital
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