The CHECK Trial: A Comparison of Headache Treatment in the Emergency Department: Compazine Versus Ketamine (Check)

This randomised, double-blind clinical trial (n=0, terminated) aimed to compare the effectiveness of ketamine (21mg/70kg) to prochlorperazine (Compazine) in treating benign headaches in the Emergency Department.

Subjects were randomised into two groups: Group 1 received standard treatment of prochlorperazine 10 mg IV along with diphenhydramine 25 mg IV, while Group 2 received Ketamine 0.3 mg/kg along with ondansetron 4 mg IV.

Subjects were monitored for vital signs and headache severity at 15, 30, 45, and 60 minutes post-intervention. At 24-48 hours post-intervention, subjects were contacted to assess pain levels and satisfaction with migraine pain management.

The study was conducted at the Mike O’Callaghan Military Hospital. Eligible participants were aged 18 to 65 years and presented to the ED with a headache. Exclusion criteria included pregnancy, breastfeeding, head trauma within the previous two weeks, and known allergies to study medications. The primary outcome measure was the pain score measured on a Visual Analogue Scale at various time points post-intervention. The study began in August 2016 and was completed in May 2017, with a total enrollment of 5 participants.

Topic Headache Disorders
Compound Ketamine
Country United States of America
Visit trial

Trial Details



Trial Number

Data attribution

A large set of the trials in our database are sourced from ClinicalTrials.gov (CTG). We have modified these post to display the information in a more clear format or to correct spelling mistakes. Our database in actively updated and may show a different status (e.g. completed) if we have knowledge of this update (e.g. a published paper on the study) which isn't reflected yet on CTG. If a trial is not sourced from CTG, this is indicated on this page and you can follow the link to the alternative source of information.