Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches

This placebo-controlled trial (n=56) will investigate the efficacy and safety of high-dose intravenous ketamine infusion in treating Chronic Daily Headaches (CDH) syndrome.

Conducted at Toronto Western Hospital and Sinai Health System, the study involves participants aged 18 or older with CDH lasting 4 or more hours on 15 or more days per month for 3 or more months.

The trial will administer either high-dose IV ketamine or saline infusions over six hours and assess various outcomes, including headache days, intensity, duration, sleep quality, physical activity, emotional well-being, and quality of life over three months. Participants will also use a pain and migraine diary and wear an actigraphy device to monitor their progress.

The study aims to provide valuable insights into the efficacy and safety of ketamine infusion for treating CDH.

Topic Headache Disorders
Compound Ketamine
Country Canada
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