The efficacy of psilocybin assisted psychotherapy (PAP) for treatment resistant obsessive-compulsive disorder (OCD), body dysmorphic disorder (BDD), and anorexia nervosa (AN); a pilot, single-arm basket trial

This single-arm, Phase I/II pilot trial (n=30) will test psilocybin-assisted psychotherapy (25mg x 2 doses, 4 weeks apart) for treatment-resistant obsessive-compulsive disorder (OCD), body dysmorphic disorder (BDD), and anorexia nervosa (AN).

The study is being conducted by Swinburne University in Victoria, Australia from October 2024 to December 2026. This “basket trial” (meaning it studies multiple conditions simultaneously) will examine participants aged 18-65 who have not responded adequately to conventional treatments. The therapy involves preparation sessions, two 8-hour dosing sessions with psilocybin, and integration sessions afterwards. Participants must be under medical care and willing to temporarily stop certain medications that might interfere with psilocybin.

The study will measure changes in condition-specific symptoms using standardised scales, along with secondary measures of depression, anxiety, quality of life, and overall functioning. This is an open-label study, meaning both participants and researchers know what treatment is being given. The trial specifically excludes people with histories of psychosis, serious suicide attempts, or recent use of psychedelics.

Topic Eating Disorders Obsessive-Compulsive Disorder
Compound Psilocybin
Country Australia
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Trial Details



Trial Number

Sponsors & Collaborators

Swinburne University of Technology
Swinburne University of Technology, located in Melbourne, Australia, is known for its focus on innovation, industry engagement, and social inclusion.

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