Psilocybin-assisted Interpersonal and Social Rhythm Therapy for Depression

This open-label trial (n=20) seeks to evaluate psilocybin-assisted interpersonal social and rhythm therapy (IPSRT) for treatment-resistant depression. Participants will receive two doses of psilocybin and eight sessions of psychotherapy.

IPSRT aims to minimize disruptions to daily routines and rhythms since these changes can lead to disrupted sleep and an unstable mood in some people.

Primary outcome measures include the feasibility of delivering this type of therapy in combination with psilocybin as well as the feasibility of recruiting patients with major depression for this treatment in New Zealand.

Topic Depression
Compound Psilocybin
Status Not yet recruiting
Results Published No
Start date 15 November 2022
End date 30 November 2023
Chance of happening 79%
Phase Phase I
Design Open
Type Interventional
Generation First
Participants 20
Sex All
Age 21- 75
Therapy Yes

Trial Details

This is a single-arm, open-label interventional study of psilocybin-assisted interpersonal and social rhythm therapy for treatment-resistant depression. 20 participants will be recruited to take part in this 8-week intervention that involves 8 sessions of psychotherapy and 2 doses of psilocybin.

NCT Number NCT05581797

Measures Used

Hamilton Depression Rating Scale
The Hamilton Depression Rating Scale (HDRS) is a multiple item questionnaire used to provide an indication of depression, and as a guide to evaluating recovery. The scale consists of 17 items which each item being scoring on a 3 or 5 point scale. The higher the score, the more likely a person is depressed.

Data attribution

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