Optimizing Microdosing and Meditation (OMM)

This open-label, randomised trial (n=24) will examine the feasibility of combining meditation with psilocybin microdosing in healthy adults.

The study, sponsored by the National University of Natural Medicine, aims to assess recruitment and retention feasibility, acceptability, safety, and tolerability of the intervention.

Participants will be randomly assigned to one of two groups: one receiving psilocybin microdoses alone and the other combining microdosing with daily online meditation practice. Both groups will undergo four supervised microdosing sessions over two weeks. Researchers will explore changes in sleep quality, heart rate variability, quality of life, and altered states of consciousness, using biometric data from Oura Rings and self-reported measures. The trial, conducted under Oregon’s Psilocybin Services programme, is expected to run from October 2024 to November 2025.

Topic Microdosing Safety Healthy Subjects
Compound Psilocybin
Country United States of America
Visit trial
Status Not yet recruiting
Results Published No
Start date 01 October 2024
End date 01 November 2025
Phase Not Applicable
Design Open
Type Interventional
Generation First
Participants 24
Sex All
Age 21- 99
Therapy No

Trial Details

The goal of this clinical trial is to test the feasibility of combining meditation with psilocybin microdosing in healthy adults. The main questions it aims to answer are: 1. Recruitment and retention feasibility 2. Acceptability, Safety and Tolerability 3. Exploratory Measures: 3.1: Explore potential changes in sleep quality and duration, heart rate variability, and other biometric outcomes captured by the Oura Ring (3rd generation). 3.2: Explore potential changes in quality of life scores 3.3: Explore potential differences in altered states of consciousness across groups 3.4: Explore qualitative data collected during sessions and at follow-up to assess satisfaction and receive feedback about the intervention. Every participant will receive the psilocybin microdosing intervention, however, half of the participants will be randomly selected to receive the meditation intervention.

Trial Number NCT06560658

Data attribution

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