Neuronal Correlates of Altered States of Consciousness (5HT2A-fMRI)

The aim of the present study is to assess the neuronal correlates of alterations in waking consciousness pharmacologically induced by a 5-hydroxytryptamine (HT)2A receptor agonist in healthy subjects using functional magnetic resonance imaging (fMRI).

Topic Healthy Subjects
Compound LSD
Country Switzerland
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Trial Details



Trial Number

Sponsors & Collaborators

University of Basel
The University of Basel Department of Biomedicine hosts the Liechti Lab research group, headed by Matthias Liechti.

Papers

Acute LSD effects on response inhibition neural networks
This double-blind, randomized, placebo-controlled, cross-over study (n=18) investigated the effects of LSD (100 µg) with respect to underlying mechanisms of visual hallucinations in healthy volunteers. Acute LSD administration significantly increased subjective feelings of impaired cognitive control and visual imagery, corresponding to deficits in inhibitory processing of external stimuli mediated via reduced activation of parahippocampal–prefrontal regions, including the anterior cingulate cortex.

A Single Dose of LSD Does Not Alter Gene Expression of the Serotonin 2A Receptor Gene (HTR2A) or Early Growth Response Genes (EGR1-3) in Healthy Subjects
Regarding the phenomenon of rapid tolerance after repeated use of LSD, this double-blind study (2017, n=15) found that a single dose of LSD (100 μg) did not alter gene expression of the serotonin (5-HT) 2A receptor gene.

Data attribution

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