LSD-Perceptual-Choice-Study

This double-blinded, placebo-controlled crossover trial (n=30) aims to investigate the effects of low doses of LSD (10-20μg) on behavioural and neural indicators of feedback and feedforward signalling in perceptual decision-making.

Conducted by the University Hospital in Basel, Switzerland, the study will involve healthy participants who will undergo multiple perceptual decision-making tasks after receiving low doses of LSD. The researchers aim to understand the impact of psychedelics on prior beliefs and evidence processing.

Each participant will attend three 5-hour study sessions separated by at least seven days. During these sessions, participants will receive either LSD or a placebo and will be under continuous supervision for approximately 4.5 hours after substance administration. Cognitive tasks, including the Changepoint task, history bias task, surround suppression task, auditory steady-state response paradigm, and motor localizer task, will be performed alongside EEG measurements.

The primary purpose of the study is basic science, and it employs a randomized, double-blinded, crossover design. Participants must be between 18 and 65 years old, fluent in German, have normal or corrected-to-normal vision, and meet other eligibility criteria.

The study started on February 20, 2024, with an estimated completion date of September 2024. Enrollment is estimated to be 30 participants. The study aims to measure changes in perceptual decision-making tasks, including the Changepoint task and history bias task, three times over the course of the study.

Topic Healthy Subjects Microdosing
Compound LSD Placebo
Country Switzerland
Visit trial
Status Recruiting
Results Published No
Start date 20 February 2024
End date 30 September 2024
Phase Not Applicable
Design Blinded
Type Interventional
Generation First
Participants 30
Sex All
Age 18- 65
Therapy No

Trial Details

The aim of the study is to characterize the effects of low doses of LSD (d-lysergic acid diethylamide) on behavioral and neural indicators of feedback and feedforward signaling in perceptual decision-making.

NCT Number NCT05976698

Sponsors & Collaborators

University of Basel
The University of Basel Department of Biomedicine hosts the Liechti Lab research group, headed by Matthias Liechti.

Data attribution

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