LSD microdosing – A repeated dosing study

This double-blind, randomized trial (n=60) conducted by Maastricht University Department of Psychology and Neurosciences, explores the effects of repeated doses of LSD (15µg) on mood, cognition, and neuroplasticity in healthy volunteers.

The study, published on 17-06-2020 and last updated on 13-12-2022, hypothesizes that the LSD group will show an increase in positive mood and subjective effects after four weeks of repeated dosing with 15 µg LSD compared to the placebo group.

The secondary objectives include examining induced cognitive performance and increased neuroplasticity. LSD is a psychedelic substance known for acute transient alterations in waking consciousness, and recent observations suggest its repeated use in low doses (microdosing) for mood enhancement.

The study aims to fill gaps in understanding the acute and sub-acute effects of a repeated microdosing schedule for four weeks. The trial, approved by ethical review and currently recruiting, involves a 1.5-year study design with placebo and 15 µg LSD interventions.

Status Completed
Results Published Yes
Start date 03 February 2020
End date 01 July 2024
Phase Not Applicable
Design Blinded
Type Interventional
Generation First
Participants 53
Sex All
Age 18- 65
Therapy No

Trial Details

The primary objective is to examine the possible positive mood and positive subjective effects following repeated doses of 15 mcg LSD compared to placebo. The secondary objective is to examine the possible induced cognitive performance and increase in neuroplasticity following repeated doses of 15 mcg LSD compared to placebo.

NCT Number 8736

Sponsors & Collaborators

Maastricht University
Maastricht University is host to the psychopharmacology department (Psychopharmacology in Maastricht) where various researchers are investigating the effects of psychedelics.

Data attribution

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