Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder

Ketamine infusions resulted in an acute reduction in global depression scores and in severity of suicidal ideation. The investigators therefore plan to investigate the feasibility and efficacy of repeated intravenous administration of ketamine in severely depressed, treatment resistant patients. The results of the study could lead to development of new strategies for treating depression.

Topic Depression Suicidality
Compound Placebo Ketamine
Country United States of America
Visit trial
Status Completed
Results Published No
Start date 01 January 2013
End date 01 November 2015
Chance of happening 100%
Phase Not Applicable
Design Blinded
Type Interventional
Generation First
Participants 37
Sex All
Age 18- 65
Therapy No

Trial Details

Ketamine infusions resulted in an acute reduction in global depression scores and in severity of suicidal ideation. The investigators therefore plan to investigate the feasibility and efficacy of repeated intravenous administration of ketamine in severely depressed, treatment resistant patients. The results of the study could lead to development of new strategies for treating depression.

NCT Number NCT01667926

Sponsors & Collaborators

Massachusetts General Hospital
Massachusettes General Hospital has launched the MGH Center for the Neuroscience of Psychedelics. The announcement has now been done via YouTube, and the formal launch will be in fall 2020.

Data attribution

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