Interactions between 3,4-methylenedioxymethamphetamine (MDMA or ’ecstasy’) and Ä9-tetrahydrocannabinol (THC or ‘marihuana’) in humans

This completed interventional trial (n=16) investigated the interactions between MDMA and THC in humans.

Conducted at UMC St. Radboud Nijmegen, the study aimed to determine how the acute effects of MDMA on cognitive function, prolactin and cortisol levels, body temperature, heart rate, and blood pressure are influenced by co-exposure to THC.

Participants, regular users of ecstasy and cannabis, received 100 mg MDMA orally and 4, 6, and 6 mg THC vaporised alone and combined. Outcome measures included cardiovascular effects, psychomotor performance, memory and learning, sedation, subjective effects, core body temperature, sympathetic responsiveness, serotonergic responsiveness, and side effects.

Recruitment began on 01-06-2006 and enrolled 16 participants, meeting eligibility criteria such as age between 18-40 years, regular use of ecstasy and THC, good physical and mental health, and written informed consent. The study employed a crossover design with double-blinded masking and placebo arm. Ethical approval was obtained on 16-05-2008.

The results from this trial were published here and here.

Topic Healthy Subjects
Compound MDMA Placebo
Country Netherlands
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Trial Details



Trial Number

Sponsors & Collaborators

Radboud University
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Data attribution

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