Esketamine and Perioperative Depressive Symptoms

Perioperative depressive symptoms (PDS) are common in population undergoing surgery, and this would be sharpened especially for complicated, high-risk major surgery. However, none of treatments could resolve this clinical problem during limited perioperative period.

The remarkable effects of ketamine on treatment resistant depression have been verified by several clinical trials and the enantiomer S-ketamine (esketamine) showed similar antidepressant efficacy with better safety in recent studies.

The efficacy and safety of esketamine administrated intra-operatively for PDS will be verified in this study. Other secondary outcomes such as anxiety, postoperative pain and psychiatric symptoms will also be investigated.

Topic Depression Pain
Compound Ketamine
Country China
Visit trial
Status Recruiting
Results Published No
Start date 19 February 2021
End date 31 December 2023
Phase Phase II Phase III
Design Blinded
Type Interventional
Generation First
Participants 564
Sex All
Age 18- 65
Therapy No

Trial Details

Perioperative depressive symptoms (PDS) are common in population undergoing surgery, and this would be sharpened especially for complicated, high-risk major surgery. However, None of treatments could resolve this clinical problem during limited perioperative period. The remarkable effects of ketamine on treatment resistant depression have been verified by several clinical trials and the enantiomer S-ketamine (esketamine) showed similar antidepressant efficacy with better safety in recent studies. The efficacy and safety of esketamine administrated intra-operatively for PDS will be verified in this study. Other secondary outcomes such as anxiety, postoperative pain and psychiatric symptoms will also be investigated.

Trial Number NCT04425473

Sponsors & Collaborators

Beijing TianTan Hospital
This company doesn't have a full profile yet, it is linked to a clinical trial.

Data attribution

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