Effect of Stimulant Drugs on Social Perception

The study will improve our understanding of the “prosocial” effects of MDMA, relative to a prototypical stimulant, methamphetamine (MA). The investigators seek to characterize the “uniquely social” effects of MDMA.

Topic Healthy Subjects
Compound Placebo MDMA
Country United States of America
Visit trial
Status Completed
Results Published Yes
Start date 01 June 2016
End date 01 January 2020
Chance of happening 100%
Phase Phase I
Design Blinded
Type Interventional
Generation First
Participants 40
Sex All
Age 18- 35
Therapy No

Trial Details

The study will improve our understanding of the "prosocial" effects of ± 3,4-Methylenedioxymethamphetamine (MDMA), relative to a prototypical stimulant, methamphetamine (MA). The investigators seek to characterize the "uniquely social" effects of MDMA.

NCT Number NCT03790618

Sponsors & Collaborators

University of Chicago
Research with psychedelics is taking place at the Human Behavioral Pharmacology Lab at the University of Chicago.

National Institute on Drug Abuse
This company doesn't have a full profile yet, it is linked to a clinical trial.

Papers

MDMA enhances positive affective responses to social feedback
This double-blind, placebo-controlled crossover trial (n=36) investigates the effects of two doses of MDMA (52.5-105mg/70kg) compared to both placebo and methamphetamine (20 mg) on responses to personalized social feedback in healthy adults. The study concludes that the higher dose of MDMA increases positive affective responses to social feedback, suggesting a potential mechanism by which MDMA may enhance social connection.

Effects of MDMA on attention to positive social cues and pleasantness of affective touch
This randomized, double-blind, placebo-controlled study (n=36) investigated the effects of MDMA (52.5 to 105 mg/kg) and methamphetamine (20 mg) in healthy young adults on behavioral and psychophysiological response to socially relevant, “affective” touch, and visual attention to emotional faces. The tests showed that MDMA positively influenced responses to affective touch, but neither drug influenced ratings of observed touch.

Data attribution

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