Effect of Intravenous S-ketamine on Opioid Consumption

This randomised, multicenter, control trial (n=352) investigates the effect of intravenous esketamine on opioid consumption and postoperative pain in female patients undergoing breast cancer surgery.

Participants will be randomly assigned to one of three groups: the placebo group, the low-dose S-ketamine group, and the high-dose S-ketamine group. The primary outcome measure is the consumption of sufentanil during surgery.

The study involves administering bolus injections of the study medication followed by continuous infusion, with assessments of pain levels and other parameters postoperatively. Patients meeting specific criteria will be included, while those with certain medical conditions or characteristics will be excluded.

The study, which commenced on October 7, 2021, is anticipated to be completed by July 7, 2024. It is conducted at the Second Affiliated Hospital of Anhui Medical University, China.

Topic Addiction
Compound Ketamine
Country China
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