Chart Review of Patients Undergoing Ketamine Treatments for Depression

This retrospective, observational trial (n=250) will review patient charts to study the effects of intravenous racemic ketamine (a 50/50 mixture of S-ketamine and R-ketamine, given at sub-anaesthetic doses) for treatment-resistant depression in a real-world outpatient setting.

The study is being conducted at the Ontario Ketamine and Infusion Centre (OKIC), a CPSO-certified outpatient clinic, and sponsored by Sunnybrook Health Sciences Centre in Canada. It will analyse data from adults aged 18 and older who have been diagnosed with major depressive disorder that has not improved after multiple standard treatments. Participants in the review must have been approved for ketamine therapy by a psychiatrist and may have previously received other neuromodulation therapies such as electroconvulsive therapy (ECT) or repetitive transcranial magnetic stimulation (rTMS).

The aim is to better understand how ketamine is being used in routine clinical practice for severe depression, its impact on symptoms (measured with tools such as the PHQ-9, BDI-II, and GAD-7), and the characteristics of patients receiving it. Baseline information includes mental health history, previous treatments, trauma history, social support, and family psychiatric history. Data will be drawn from treatments delivered between April 2022 and June 2025.

Topic Depression Treatment-Resistant Depression
Compound Ketamine
Country Canada
Visit trial

Trial Details



Trial Number

Sponsors & Collaborators

Sunnybrook Health Sciences Centre
This company doesn't have a full profile yet, it is linked to a clinical trial.

Data attribution

A large set of the trials in our database are sourced from ClinicalTrials.gov (CTG). We have modified these post to display the information in a more clear format or to correct spelling mistakes. Our database in actively updated and may show a different status (e.g. completed) if we have knowledge of this update (e.g. a published paper on the study) which isn't reflected yet on CTG. If a trial is not sourced from CTG, this is indicated on this page and you can follow the link to the alternative source of information.