Psychedelic Research Links March 2022

This is all the other psychedelic research that comes out in March 2022. These papers don’t (yet) have their own page in our database.

This page will be updated (almost) every day.

You can find all interesting papers in our Papers Database.

Related Papers

Use CTRL/CMD+F to quickly search if anything relevant for you has been published this month.

• Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites (rodent study, ibogaine metabolism)
• Effects of the 5-HT_2A receptor antagonist volinanserin on head-twitch response and intracranial self-stimulation depression induced by different structural classes of psychedelics in rodents (rodent study, head-twitch response to volinanserin and LSD)
• Naturalistic Entheogenics: Précis of Philosophy of Psychedelics (precis to a new book from psychedelic philosopher Chris Letheby)
• Effects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats (roden study)
• The Acceptance/Avoidance-Promoting Experiences Questionnaire (APEQ): A theory-based approach to psychedelic drugs’ effects on psychological flexibility (validation of a psychological model of acceptance/avoidance-promoting psychedelic experiences)
• Methodological Challenges in Psychedelic Drug Trials:Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression (EPIsoDE) – Rationale and Study Design (addressing some of the challenges in psychedelic clinical research)
• A comparison of the safety, feasibility, and tolerability of ECT and ketamine for treatment-resistant depression (review, assess the safety nd tolerability of using ketamine and electroconvulsion therapy)
• Heart rate (HR) and heart rate variability (HRV) response to inhaled N, N-dimethyltryptamine (N, N-DMT): A case report (n=1, same dose but shorter duration of trip (600 to 400 seconds, “Inhaled N, N-DMT induced acute transient elevations in HR and a temporal association was observed of a pronounced elevation in average daily HRV one-day following the N, N-DMT use.“)
• Can psychedelic-assisted psychotherapy play a role in enhancing motivation to change in addiction treatment settings? (commentary)
• Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain (review)
• Ketamine in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review (review, shows scant evidence, 3 RCTs for the use of ketamine for OCD)
• Development of an E. coli-based norbaeocystin production platform and evaluation of behavioural effects in rats (novel method for gram-scale production of norbaeocystin (a psilocybin alkaloid) in Escherichia coli)
• A systematic literature review and meta-analysis of the effect of psilocybin and methylenedioxymethamphetamine on mental, behavioural or developmental disorders (meta analysis)
• Behavioural Psychedelics: Integrating Mind and Behavior to Improve Health and Resilience (theory, introduction of behavioural psychedelics, defined as the study of psychedelics to foster intentional changes in habits and behaviours to improve health and resilience)
• Perspective: Can psychedelic-assisted therapy be a promising aid in compulsive sexual behaviour disorder treatment? (a perspective on the possible effectiveness and mechanisms of action of psychedelics’ introduction in the treatment of Compulsive Sexual Behavior Disorder (CSBD))
• Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain (review)
• Top Ten Tips Palliative Care Clinicians Should Know About Psychedelic-Assisted Therapy in the Context of Serious Illness (“10 evidence-informed tips for PC clinicians synthesized through consultation with interdisciplinary and international leading experts in the field” )
• Adverse Effects After Ayahuasca Administration in the Clinical Setting (letter to the editors)
• The doors of precision: Reenergizing psychiatric drug development with psychedelics and open access computational tools (opinion, “psychedelics paried with new computational tools might help by-pass the imprecision of psychiatric diagnosis“)
• Serotonin transporter availability, neurocognitive function and their correlation in abstinent 3,4-methylenedioxymethamphetamine users (review, MDMA’s long-term effects on SERT availability and cognitive functioning)
• Phenomenological assessment of psychedelics induced experiences: Translation and validation of the German Challenging Experience Questionnaire (CEQ) and Ego-Dissolution Inventory (EDI) (Assessment and validation of the German CEQ and EDI)
• 3,4-Methylenedioxymethamphetamine Quantification via Benchtop ¹H qNMR Spectroscopy: Method Validation and its Application to Ecstasy Tablets Collected at Music Festivals (use of NMR spectroscopy to conduct quantitative analysis of MDMA)
• Reply to: 5-MeO-DMT has not been found in traditional ayahuasca preparations and the combination of 5-MeO-DMT with MAOIs is dangerous (letter to the editor)
• The promises and perils of psychedelic pharmacology for psychiatry (review)
• Can psilocybin be safely administered under medical supervision? A systematic review of adverse event reporting in clinical trials (review)
• Shared and distinct brain regions targeted for immediate early gene expression by ketamine and psilocybin (exploring psilocybin/ketamine gene expression in regions of the brain)
• Counselors’ attitudes toward psychedelics and their use in therapy (this study presents the results of a survey of counseling professionals’ attitudes toward psychedelics and psychedelic therapy)
• Ketamine for Depression: Advances in Clinical Treatment, Rapid Antidepressant Mechanisms of Action, and a Contrast with Serotonergic Psychedelics (review)
• Ecstasy (MDMA): A rebellion coherent with the system (“this study attempts to demonstrate the relevance of the socio-cultural model of drugs in explaining the impressive development of ecstasy in the last 45 years“)
• Who is the typical psychedelics user? Methodological challenges for research in psychedelics use and its consequences (review, “despite a resurgence in research on psychedelics over the last two decades, we still have little insight into the psychedelics user population“)
• Understanding Kratom Use: A Guide for Healthcare Providers (review, science of kratom and recommendations for best practices)
• Race, Ethnic, and Sex Differences in Prevalence of and Trends in Hallucinogen Consumption Among Lifetime Users in the United States Between 2015 and 2019 (examining race, ethnic and sex differences among lifetime psychedelic users)
• Perspective: Can psychedelic-assisted therapy be a promising aid in compulsive sexual behavior disorder treatment? (theory-builiding)
• Ketamine for Depression: Advances in Clinical Treatment, Rapid Antidepressant Mechanisms of Action, and a Contrast with Serotonergic Psychedelics (book chapter)
• Are periodontitis, dental caries and xerostomia more frequently present in recreational ecstasy users? (cross-sectional study of dental records)
• Set, Setting, and Clinical Trials: Colonial Technologies and Psychedelics (book chapter, “ethnographic work on technologies of healing, pharmaceutical and psychedelic clinical trials, and ceremonial uses of the Amazonian herbal brew ayahuasca“)
• Pathological Delta Oscillations in Hallucinogen Persisting Perception Disorder: A Case Report (case study)
• How Important Is a Guide Who Has Taken Psilocybin in Psilocybin-Assisted Therapy for Depression? (“we sought to assess the importance of a guide who had used psilocybin to potential clients with depressive symptoms”)
• Pharmacological Action of LSD (chapter)
• A cluster of 25B-NBOH poisonings following exposure to powder sold as lysergic acid diethylamide (LSD) (case series, exposure to 25B-NBOH)
• An Exploration of the Aberrant Perceptions Experienced by Westerners in the Peruvian Amazon Amid Shipibo Ayahuasca Practices (anthropology  “fieldwork conducted in the Peruvian Amazon amid the Shipibo, focusing on the experiences of the spiritual seekers who came to them in search of healing or self-discovery“)
• Retraction: Long-term systemic administration with low dose of 3,4-methylenedioxymethamphetamine causes photoreceptor cell damage in CD1 mice (article retraction)
• How to account for hallucinations in the interpretation of the antidepressant effects of psychedelics: a translational framework (“a translational framework based on establishing pharmacokinetic/pharmacodynamic relationships in rodents and humans for hallucinogenic  and therapeutic effects“)
• Past-Year Ketamine Use: Evidence from a United States Population, 2015-2019 (“the present study estimated the prevalence of past-year ketamine use among a national sample of US adults“)
• Selective Serotonin Receptor Modulators for Use in the Treatment of Psychological Disorders (a look at the 5-MeO-DMT that GH Research have filed a patent application for)
• Enlightening the “Spirit Molecule”: Photomodulation of the 5-HT2A Receptor by a Light-Controllable N,N-Dimethyltryptamine Derivative (a tool to study the receptor signalling induced by DMT)
• Psychedelics and environmental virtues (“we argue that responsible psychedelic use can reliably catalyze the development of a key environmental virtue known as living in place“)
• Ketamine – Undrawn Lines between Medical and Recreational Use – Implications for Clinical Practice
• Chaplaincy and Psychedelic-Assisted Therapy: Opportunities and Barriers (the role of chaplains in psychedelic therapy)
• Extracorporeal Membrane Oxygenation Support in Refractory Multi-organ Failure by 3,4-Methylenedioxymethamphetamine Intoxication (“Ecstasy”) (case study)
• Seeing oneself through the eyes of another: A look at psychedelic insight (case study, applying four models to explore how seeing one’s self through the eyes of another during a psychedelic experience is beneficial)
• Signaling Snapshots of 5-HT _2BR Activated by the Prototypical Psychedelic LSD (LSD action study, under review)
• The effect of 3,4-methylenedioxymethamphetamine (MDMA) on human genetic material: an in vitro study (cell-based study, “It seems to affect human T lymphocytes by epigenetic and DNA replication modifications“)