2C-B (4-bromo-2,5-dimethoxyphenethylamine) is a synthetic psychedelic substance discovered by Alexander Shulgin in 1974. Initially used under the name “Nexus” for enhancing sexual experiences, it gained popularity in the 1980s as an MDMA alternative. Today, 2C-B is illegal in most countries but remains a subject of interest in psychedelic research and recreational use.

The effects of 2C-B are often described as a combination of MDMA and LSD, offering both empathogenic and hallucinogenic properties. Dosage typically ranges from 5 to 35 mg, with effects lasting 4 to 8 hours. Users report increased energy, empathy, introspection, and visual hallucinations. The substance is considered relatively safe compared to other psychedelics, with no reported overdose deaths. However, proper dosing and substance testing is crucial due to adulteration risks.

Current research on 2C-B is severely limited, with only a dozen human studies and a handful of clinical trials having been done with the drug. However, some studies suggest potential therapeutic applications, particularly in psychotherapy as a follow-up to MDMA-assisted sessions. 2C-B is part of a larger family of 2C compounds, each with unique properties and effects.

The legal status of 2C-B as a Schedule I substance in many countries presents significant challenges for research and medical use. This classification also impacts individual users, emphasizing the importance of harm reduction strategies and education about responsible use.

Looking forward, the growing interest in psychedelic research may lead to renewed scientific and commercial exploration of 2C-B and related compounds.

β take: 2C-B is an extraordinary compound which enlists psychedelic effects whilst keeping a certain level of lucidity available. The lack of research and commercial interest alas don't make me hopeful that it will become a formal medicine in the near future. Its unique combination of psychedelic and empathogenic effects, while potentially limiting its specific medical applications, contributes to its popularity in recreational settings. This dual nature presents both challenges for clinical research and opportunities for personal exploration.

History of 2C-B

The renowned American chemist Alexander ‘Sasha’ Shulgin is often celebrated as the “godfather of ecstasy” for his work with MDMA. Next to rediscovering MDMA, he has synthesized hundreds of novel molecules, including 2C-B. Shulgin’s exploration of psychedelic phenethylamines was driven by his fascination with the potential therapeutic benefits of these substances. He documented his findings in the book PiHKAL: A Chemical Love Story, co-authored with his wife Ann Shulgin, where he listed 2C-B among his “magical half-dozen” of the most significant psychedelic phenethylamines. This select group also included mescaline, DOM, 2C-E, 2C-T-2, and 2C-T-7.

In the 1970s, a small number of psychotherapists in the United States began using 2C-B as an adjunct in therapy sessions. They found that it helped patients break down ego defences and access repressed emotions and memories. The compound’s short duration and relative mildness made it particularly suitable for therapeutic settings. Shulgin himself considered 2C-B to be one of his greatest creations, noting its unique combination of introspective and empathogenic effects.

The recreational use of 2C-B started to gain traction in the 1980s and 1990s, particularly after MDMA was classified as a Schedule I substance in 1985. As MDMA became illegal, 2C-B emerged as a popular alternative in the rave and club scene. It was marketed under various names such as “Nexus,” “Erox,” and “Performax,” often sold in adult video stores and head shops. These products were advertised as aphrodisiacs, claiming to enhance libido and sexual pleasure.

2C-B & You

While we don’t encourage the use of illegal substances, we recognize that people may choose to use 2C-B. If you’re considering using 2C-B, it’s crucial to prioritize safety and be well-informed. Here’s some essential information for harm reduction:

Dosage

2C-B is potent in small amounts, and the dose-response curve is steep. This means a small increase in dose can lead to a much stronger experience.

• Threshold dose: 5-10 mg
• Light dose: 10-15 mg
• Common dose: 15-25 mg
• Strong dose: 25-35 mg

Remember, these are general guidelines. Individual reactions can vary significantly based on body weight, metabolism, and sensitivity.

Route of Administration

2C-B can be taken orally (most common), nasally (snorted), or rectally. Each method has different onset times and intensity:

• Oral: Effects start in 45-75 minutes, peak at 2-3 hours, last 4-8 hours
• Nasal: Faster onset (15-30 minutes) but more painful and intense
• Rectal: Quick onset (15-30 minutes), stronger effects, shorter duration

Oral use is generally recommended for a more controllable experience.

Set and Setting

Your mindset (“set”) and environment (“setting”) significantly influence the experience:

• Choose a safe, comfortable location
• Have a sober trip sitter present
• Avoid using it when in a negative emotional state
• Clear your schedule for the day of use and the following day

Interactions and Contraindications

• Avoid combining 2C-B with other substances, especially MAOIs, which can lead to dangerous interactions
• Don’t use if you have heart conditions, high blood pressure, or are prone to seizures
• Be cautious if you have a history of mental health issues, particularly psychosis or severe anxiety

Physical Effects to Be Aware Of

• Increased heart rate and blood pressure
• Nausea (especially during onset)
• Muscle tension
• Difficulty urinating
• Increased body temperature

Psychological Effects

• Altered perception of time and space
• Visual and auditory changes
• Emotional amplification
• Potential for challenging psychological experiences

Harm Reduction Tips

1. Start with a low dose, especially if it’s your first time
2. Test your substance with reagent kits to ensure it’s actually 2C-B
3. Stay hydrated, but don’t overhydrate
4. Have easy-to-eat snacks available
5. Create a calm, safe environment with soft lighting and comfortable seating
6. If anxiety occurs, remember the effects are temporary. Deep breathing and changing your environment can help

Integration and Aftercare

• Allow time for rest and reflection after the experience
• Discuss your experience with trusted friends or a therapist
• Be gentle with yourself as you process the experience

Remember, the safest approach is not to use 2C-B at all. If you do choose to use it, these guidelines can help minimize potential risks. Always prioritize your physical and mental well-being.

β take: Taking 2C-B with friends or a partner can be a magical experience filled with connection and insights. Taking 2C-B at a club or festival might be just as overwhelming as mushrooms or LSD (though I hear it's common to use 2C-B in South American clubs). 2C-B can be done in multiple stages (i.e. redosing), so I would like to repeat the suggestion to start low; you can always add, not subtract.

Future of 2C-B

Unlike some other psychedelic compounds, such as MDMA or psilocybin, which are making significant strides in clinical research and potential medical approval, the future of 2C-B remains largely uncertain and limited.

Legal and Research Outlook

No major initiatives or clinical trials are currently focused on developing 2C-B as a therapeutic tool. Its status as a Schedule I substance in many countries continues to pose significant barriers to research and medical development. Without substantial changes in drug policies or a surge in research interest, it’s unlikely that 2C-B will see major legal or medical advancements shortly.

While some researchers acknowledge 2C-B’s unique properties – such as its shorter duration and blend of empathogenic and psychedelic effects – that could potentially be valuable in therapeutic settings, there’s currently little momentum to explore these possibilities within formal scientific and medical frameworks.

Continued Underground Presence

Given the lack of mainstream research or legal reform efforts, it’s likely that 2C-B will continue to exist primarily in underground and recreational settings. Its popularity in certain subcultures and on the psychedelic scene suggests that it will maintain a presence in these circles.

However, underground markets’ absence of regulation and quality control poses ongoing user risks. This underscores the continued importance of harm reduction efforts and education about safe use practices.

Potential for Change?

While the immediate future doesn’t suggest major changes for 2C-B’s status, the broader psychedelic renaissance could potentially influence its trajectory. As attitudes towards psychedelic substances evolve and research expands, there’s a possibility that interest in 2C-B could grow. However, any significant shifts would likely be part of wider drug policy reforms rather than 2C-B-specific initiatives.

External references for 2C-B

All resources available on Blossom are directly linked on this topic page. Find even more background about this topic with these external references.

1. TripSitter. (n.d.). 2C-B: Effects, dosage, & safety. Retrieved August 1, 2024, from https://tripsitter.com/2cb/
2. Shulgin, A. T., & Shulgin, A. (1991). PIHKAL: A chemical love story (Vol. 963009605). Berkeley, CA: Transform Press.
3. Trimbos-instituut. (n.d.). Factsheet 2C-B. Retrieved August 1, 2024, from https://www.trimbos.nl/aanbod/webwinkel/af2063-factsheet-2c-b/
4. PsychonautWiki. (n.d.). 2C-B. Retrieved August 1, 2024, from https://psychonautwiki.org/wiki/2C-B