Understanding Neuroplasticity Induced by TrYptamines (UNITy): the effects of dimethyltryptamine (DMT) on drinking

This randomised, double-blind, placebo-controlled trial (n=60) will study the effects of dimethyltryptamine (DMT) on drinking behaviour and neuroplasticity in hazardous and harmful alcohol drinkers (AUD) who are not currently seeking treatment.

The study, called Understanding Neuroplasticity Induced by TrYptamines (UNITy), is being conducted by researchers at University College London from October 2020 to December 2027. It aims to assess how DMT might alter brain connectivity and modify memory associations related to drinking, potentially leading to reduced alcohol consumption.

Participants will undergo three in-person visits over two weeks, followed by remote follow-ups over nine months. The protocol includes questionnaires, cognitive tests, brain imaging (MRI and EEG), and an intravenous DMT infusion. Researchers will measure changes in drinking behaviour, mood, and brain activity. The study may provide insights into the mechanisms of psychedelic drugs and their potential role in treating substance use disorders.

Participants must be healthy adults aged 21-65 who are hazardous or harmful drinkers but not currently in treatment. Strict eligibility criteria are in place to ensure participant safety due to the potent effects of DMT.

Topic Addiction Alcohol Use Disorder
Compound DMT
Country United Kingdom
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