Ketamine for Methamphetamine Use Disorder (KMD)

This randomised, double-blind, placebo-controlled trial (n=120) will study the efficacy of intravenous (IV) ketamine versus IV midazolam in treating adults with moderate to severe methamphetamine use disorder (MUD).

Conducted by the University of Texas Southwestern Medical Center, this 12-week trial involves administering either IV ketamine (0.50 mg/kg) or IV midazolam (0.02 mg/kg) over 40 minutes for a total of eight infusions across six weeks. Participants will also attend weekly medical management sessions and cognitive behavioural therapy (CBT) sessions.

The primary aim is to determine if IV ketamine is superior to midazolam in reducing methamphetamine use, with additional assessments for safety and adherence to treatment.

Topic Opioid Use Disorder Addiction
Compound Ketamine
Country United States of America
Visit trial
Status Not yet recruiting
Results Published No
Start date 01 August 2024
End date 01 April 2027
Phase Phase II
Design Blinded
Type Interventional
Generation First
Participants 120
Sex All
Age 18- 65
Therapy Yes

Trial Details

This study aims to determine whether treatment response with IV ketamine is superior to treatment response with IV midazolam in adults with moderate to severe MUD. The study design is a 12-week randomized, double-blind, controlled trial comparing intravenous (IV) ketamine against IV midazolam, delivered over six weeks in 120 adults with moderate to severe methamphetamine use disorder (MUD).

NCT Number NCT06496750

Sponsors & Collaborators

University of Texas
The University of Texas is conducting research with psychedelics across locations in Houston, Austin, Dallas and San Antonio.

Data attribution

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