Glutamate Emotion Memory Study

This interventional trial (n=60) conducted by the University of Oxford aims to assess the effects of ketamine on autobiographical memory, emotional processing, and decision-making in individuals with treatment-resistant depression (TRD).

Participants will receive either a single intravenous injection of ketamine hydrochloride or a placebo. The study will investigate the impact of ketamine on negative emotional bias associated with autobiographical memories, brain circuits linked to autobiographical memories, emotional processing, and reward processing. It will also explore various aspects of emotional recognition, recall, and decision-making using computer-based tasks.

The primary outcome measures include changes in the magnitude of negative and positive valence adjectives in autobiographical memory tasks and brain activation measured by functional magnetic resonance imaging (fMRI). The study, which began in July 2022, is estimated to complete in February 2024 with an enrollment of 60 participants aged between 20 to 60 years. Contact for participation is available through the Department of Psychiatry, University of Oxford.

Topic Treatment-Resistant Depression Depression
Compound Placebo Ketamine
Country United Kingdom
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University of Oxford
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