Effect of Psychedelic VR-augmented Therapy on Patients With Clinical Depression

This randomised controlled trial (n=45) aims to evaluate the effect of psychedelic virtual reality-augmented therapy on patients with clinical depression.

The study, conducted by the University of Tartu, Estonia, seeks to explore the therapeutic potential of psychedelic-like experiences simulated through virtual reality (VR) in alleviating depressive symptoms. The trial involves two arms: the experimental arm incorporates ‘Psyrreal,’ a VR experience emulating psychedelic effects, while the control arm uses ‘Routine Realms,’ a similar VR experience without psychedelic elements. The primary goal is to assess the impact of the VR-induced psychedelic-like experiences on depressive symptoms. Additionally, the study aims to identify potential mediators contributing to observed therapeutic outcomes.

Participants, aged 18 to 65, with persistent depressive symptoms, will undergo a comprehensive psychiatric evaluation to confirm eligibility. The trial utilises a randomised allocation model with double masking to assign participants to the experimental or control groups.

The study will measure changes in depressive symptoms using the Emotional State Questionnaire 2 depression subscale score at three time points: on the day of intervention, and two weeks and two months post-intervention. Secondary outcome measures include assessments of mood changes, alterations in consciousness, psychological insight, and acceptance-related beliefs. The trial will involve a total of 45 participants and is estimated to be completed by November 2024.

Topic Depression
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