Psilocybin as a tool for enhancing cognitive flexibility

This interventional trial (n=60), conducted by the University Maastricht (UM), investigates the effects of psilocybin (12mg/70kg) on cognitive flexibility, specifically divergent thinking and goal-directed behaviour.

The study aims to assess drug-induced changes in performance by comparing psilocybin to a placebo, both before and after an induction of stress. Additional parameters include evaluating frontal-subcortical connectivity alterations, neurotransmission of glutamate and GABA, subjective experiences, pharmacokinetics, and cortisol levels. The study involves up to 360 minutes of measurements after drug intake on the first testing day and up to 2.5 hours of follow-up measurements on the second testing day.

The primary sponsor is the University of Maastricht. The study, pending recruitment completion, started on May 1, 2017, with an anticipated enrolment of 60 participants.

Compound LSD Placebo
Country Netherlands
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Trial Details



Trial Number

Sponsors & Collaborators

Maastricht University
Maastricht University is host to the psychopharmacology department (Psychopharmacology in Maastricht) where various researchers are investigating the effects of psychedelics.

Data attribution

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