Salivary Oxytocin as a Biomarker in Psychedelic Assisted Psychotherapy (PAP_OXT)

This observational pilot study (n=10) will examine salivary oxytocin levels during a single dose of LSD as part of psychedelic-assisted psychotherapy (PAP) for anxiety disorders or depression.

The study, conducted by Geneva University Hospitals in Switzerland, aims to gather preliminary data on the reactivity of salivary oxytocin during LSD-assisted therapy. Participants will be selected from patients in the Addiction Department who have received approval for compassionate treatment with LSD for refractory anxiety or depression. On the day of their LSD treatment, participants will provide four saliva samples to measure oxytocin levels, in addition to completing standard self-report questionnaires.

The researchers will not interfere with the usual clinical routine, but will collect these additional biomarker measurements. This pilot study could provide valuable insights into the physiological mechanisms underlying the therapeutic effects of psychedelic-assisted psychotherapy, potentially identifying salivary oxytocin as a relevant biomarker for future research in this field.

Topic Depression Anxiety
Compound LSD
Country Switzerland
Visit trial
Status Recruiting
Results Published No
Start date 05 August 2024
End date 31 December 2424
Phase Not Applicable
Design Open
Type Observational
Generation First
Participants 10
Sex All
Age 18- 50
Therapy Yes

Trial Details

The main objective of this pilot study is to obtain preliminary data on the reactivity of salivary oxytocin during a single LSD intake as part of PAP treatment for anxiety disorders or depression (treatment authorisations granted in advance by the Federal Officie of Public Health for compassionate use of the substance). There will be no interference with the usual clinical routine in our Service. The protocol is only for taking additional saliva measurements to measure oxytocin levels on the day of treatment. Participants will be asked to give 4 saliva samples the day of their LSD treatment .In addition they will fill-in self-report questionnaires which are part of the clinical routine.

NCT Number NCT06557239

Sponsors & Collaborators

University Hospital Geneva
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Data attribution

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