Psilocybin for Prolonged Grief Disorder

This open-label, single-arm trial (n=12) will study the effects of a single dose of psilocybin (25mg) on individuals with prolonged grief disorder (PGD).

Conducted by the University of Virginia, this early Phase I trial aims to evaluate the feasibility of using psilocybin-assisted therapy for PGD, a condition marked by intense and persistent grief.

Participants will undergo a preparation session, receive psilocybin in a monitored setting, and then engage in two integration sessions. The study will assess changes in grief symptoms using the Inventory of Complicated Grief (ICG) and will also measure PTSD-related symptoms with the Davidson Trauma Scale (DTS). Additionally, it will explore whether psilocybin induces mystical, spiritual, or insightful experiences that contribute to symptom relief. Follow-up assessments will take place at 1, 3, and 6 months post-treatment. The trial is expected to begin in February 2025 and conclude in October 2026.

Topic Depression
Compound Psilocybin
Country United States of America
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