MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSD (MDMA-bCBCT)

This open-label trial (n=16) will examine the preliminary effectiveness of MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy (MDMA-bCBCT) in improving chronic PTSD and relationship functioning in veterans and their intimate partners within the VA San Diego Healthcare System.

Conducted by Dr. Leslie Morland at the San Diego Veterans Healthcare System, the study involves 8 sessions of bCBCT combined with two full-day MDMA sessions for the veteran diagnosed with PTSD. The veteran will receive 80 mg of MDMA HCl in the first session and 100 mg in the second, with supplemental doses. The partners will participate in preparatory sessions and Emotion Focused Integrative sessions.

Outcome measures include clinician-rated PTSD symptoms, relationship satisfaction, and other psychological factors. The study started in October 2023 and is expected to conclude by December 2024.

Find the full study protocol here.

Topic PTSD
Compound MDMA
Country United States of America
Visit trial
Status Recruiting
Results Published No
Start date 06 October 2023
End date 31 December 2024
Phase Phase III
Design Open
Type Interventional
Generation First
Participants 16
Sex All
Age 18- 99
Therapy Yes

Trial Details

The goal of this pilot trial is to examine the preliminary effectiveness of MDMA-facilitated bCBCT for improving chronic PTSD and relationship functioning in a sample of veterans and their intimate partners seeking care within the VA San Diego Healthcare System.

NCT Number NCT05979844

Sponsors & Collaborators

US Department of Veteran Affairs
The US Department of Veteran Affairs is playing an important role in the psychedelic renaissance by exploring and monitoring advancements in psychedelic therapies and the viability of these therapies for veterans with PTSD.

Data attribution

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