LSD microdosing

This interventional trial (n=27), led by Maastricht University with sponsorship from the Department of Psychology and Neurosciences, involves exploring the dose-response relationship in LSD-induced subjective and cognitive effects in healthy volunteers.

The study, focusing on LSD microdosing, aims to characterise the effects of small doses (5, 10, and 20 µg) compared to a placebo. The hypothesis is that higher doses of LSD will be associated with greater and potentially qualitatively different subjective effects.

The secondary objective includes assessing changes in cognitive performance. The study duration is one year, and the intervention involves administering placebo and LSD doses. Eligible participants, aged 18-40, with previous psychedelic experience, will be enrolled in a crossover, double-blinded, randomised controlled trial. The trial, initiated on May 1, 2018, is pending recruitment completion with 27 anticipated participants.

Topic Microdosing
Compound LSD Placebo
Country Netherlands
Visit trial
Status Not yet recruiting
Results Published No
Start date 01 May 2018
End date 30 December 2024
Phase Not Applicable
Design Blinded
Type Interventional
Generation First
Participants 27
Sex All
Age 18- 40
Therapy No

Trial Details

The primary objective is to characterize the dose-response relationship in LSD-induced subjective effects. The secondary objective is to characterize the dose-response relationship in LSD-induced changes in cognitive performance.

NCT Number

Sponsors & Collaborators

Maastricht University
Maastricht University is host to the psychopharmacology department (Psychopharmacology in Maastricht) where various researchers are investigating the effects of psychedelics.

Data attribution

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