Ketamine Infusion Therapy for the Treatment of PTSD in Paramedics

This is an observational study to assess the change in several psychological screening tools before and after a series of six ketamine infusions in paramedics who suffer from post traumatic stress disorder (PTSD) as a result of working in emergency medical services.

Topic PTSD Anxiety
Compound Ketamine
Country United States of America
Visit trial
Status Completed
Results Published No
Start date 02 May 2019
End date 22 February 2021
Chance of happening 100%
Phase Not Applicable
Design Open
Type Interventional
Generation First
Participants 7
Sex All
Age 18- 75
Therapy No

Trial Details

Working as a paramedic in a prehospital emergency medical services system (EMS) has been shown to lead to increased incidence of post traumatic stress disorder (PTSD) and increased risk of suicide in prehospital personnel. In recent years a growing body of literature has shown that ketamine hydrochloride can be an effective treatment for PTSD. This study seeks to look specifically at paramedic level emergency medical technicians ("paramedics") with PTSD related to their prehospital work and assess whether ketamine infusion therapy can be an effective treatment for them. This is an observational study where the results of psychological screening tools that are administered before and after a six-infusion series are reported. Additionally the same assessment tools will be administered again 30 days after the final treatment to measure the durability of any changes. The participants will receive the Periodic Health Questionnaire-9 (PHQ-9), the PTSD Checklist for Diagnostic and Statistical Manual, DSM-5 (PCL-5), the Alcohol Use Disorders Identification Test (AUDIT), and the Beck Anxiety Inventory (BAI) before the infusions, after the series of six, and thirty days later. Additionally, after the series of six infusions, participants will receive the Revised Mystical Experience Questionnaire-30 (RMEQ-30) and a one question survey to assess the impact of the experiential aspect of ketamine.

NCT Number NCT03947099

Sponsors & Collaborators

Klarisana Physician Services
This company doesn't have a full profile yet, it is linked to a clinical trial.

Measures Used

Patient Health Questionnaire for Depression
The PHQ-9 is the module of the Patient Health Questionnaire focusing on major depressive disorder (MDD). It is a 3-page questionnaire that can be entirely self-administered by the patient, after which it is checked by a medical professional. The PHQ-9 consists of 9 items. If 5 or more criteria have been met, the patient is diagnosed with depression.

Data attribution

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