A potential role for psilocybin in the treatment of obsessive-compulsive disorder

A comprehensive (2020) review of psilocybin in the treatment for OCD. The current research is limited in scope (one trial), but points towards possible mechanisms and effectiveness.

Abstract of A potential role for psilocybin in the treatment of obsessive-compulsive disorder

“The recent revivification of interest in the therapeutic use of psychedelics has had a particular focus on mood disorders and addiction, although there is reason to think these drugs may be effective more widely. After outlining pertinent aspects of psilocybin and obsessive-compulsive disorder (OCD), the current review summarizes the evidence indicating that there may be a role for psilocybin in the treatment of OCD, as well as highlighting a range of potential therapeutic mechanisms that reflect the action of psilocybin on brain function. Although the current evidence is limited, that multiple signals point in directions consistent with treatment potential, alongside the psychological and physiological safety of clinically administered psilocybin, support the expansion of research, both in animal models and in further randomized controlled trials, to properly investigate this potential.”

Author: Edward Jacobs

Summary of A potential role for psilocybin in the treatment of obsessive-compulsive disorder