Psychedelic Research Papers

New insights into the clinical and nonclinical effects of psychedelic substances: An integrative review
This review (2022) explores the potential of psychedelics in treating mental health disorders, their short- and long-term effects on recreational users, and the neurological and cognitive processes responsible for their effects using the most up to date research. The positive findings of psilocybin for depression (MDD) and anxiety are highlighted. The mystical experience (MEQ) also plays a large role, but individual differences (for whom does it work) are still not well examined.
European Psychologist
May 2022
Cited by 0
The role of extracellular serotonin and MDMA in the sensitizing effects of MDMA
This rodent study (2022) assessed the impact repeated high-dose exposure to MDMA has on markers of serotonin neurotransmission and if this is related to the sensitizing effects of MDMA. The results suggest that the sensitizing effects of MDMA are not due to changes in MDMA-produced synaptic overflow of serotonin but are more likely related to alterations in serotonin receptor mechanisms and/or dopamine neurotransmission.
Behavioural Brain Research
May 2022
Cited by 0
Incilius alvarius cell-based synthesis of 5-MeO-DMT
This preprint (2022) describes the synthesis of 5-MeO-DMT from a cell line from tissue obtained from the parotoid gland (saliva) of the Sonoran Desert toad (Incilius alvarius). The samples were successfully tested for 5-MeO-DMT but may also contain other 'entourage' compounds. Such methods help to relieve ecological pressures due to the increasing demand for 5-MeO-DMT.
Biorxiv
May 2022
Cited by 0
The Psychedelic Integration Scales: Tools for Measuring Psychedelic Integration Behaviors and Experiences
This theory-building paper (2022) describes the development and initial validation of the Integration Engagement Scale (IES) to capture positive behavioural engagement with integration and the Experienced Integration Scale (EIS) to capture internal aspects of feeling integrated following a psychedelic experience. The scales were designed to inform the creation of enhanced integration support and the initial data indicates the scales are valid and reliable.
Frontiers in Psychology
May 2022
Cited by 0
Cognitive Function Mediates the Anti-suicide Effect of Repeated Intravenous Ketamine in Adult Patients With Suicidal Ideation
This study (n=86) assessed the effects of six infusions of ketamine (35mg/70kg) over 2 weeks on suicidality in patients with depression. Next to the Beck Scale for Suicide Ideation (SSI) and the Montgomery-Asberg Depression Rating Scale (MADRS), the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery was also used. MADRS total score and processing speed (but not other cognitive domains) were significant partial mediators of the association between ketamine treatment and improvements in suicidal ideation.
Frontiers in Psychiatry
May 2022
Cited by 0
Traditional Amazonian medicine in addiction treatment: Qualitative results
This pre-print (2022) used open-ended interviews followed by thematic analysis to assess the perspective of patients (n=9) who underwent treatment with ayahuasca in the Takiwasi Center (rehabilitation centre). While the therapeutic effects are supported, the complexities are also discussed.
Academic Psychiatry
May 2022
Cited by 0
Chronic Treatment With Psilocybin Decreases Changes in Body Weight in a Rodent Model of Obesity
This animal study (2022) explored the effects of psilocybin and metformin (a drug used to manage blood sugar) in a rat model of obesity. In the low - not medium - and high dose psilocybin groups, a significant decrease in body weight was observed compared to controls. The metformin (type 2 diabetes medicine) group produced a greater decrease in body weight than either psilocybin group or the control. The medium dose psilocybin group was terminated from the study as they were incorrectly treated with the drug.
Frontiers in Psychiatry
May 2022
Cited by 0
Psychedelic Resting-state Neuroimaging: A Review and Perspective on Balancing Replication and Novel Analyses
This paper (2022) by some of the most well-known authors in the field of psychedelics, reviews 42 studies where resting-state functional magnetic resonance imaging (fMRI) was used and assessed methodological variations across studies. Nearly all studies varied in data processing and analysis methodology. Guidelines are proposed to ensure consistency across the field.
Academic Psychiatry
May 2022
Cited by 0
Views on Using Psychoactive Substances to Self-Manage Functional Neurological Disorder: Online Patient Survey Results
This survey study (n=980) assessed the perspectives of patients with functional neurological disorders (FND) (e.g. multiple sclerosis, stroke) on novel treatments like psychedelic therapoy. 15% of respondents reported using illicit substances to manage their symptoms, with the majority expereincing no or minimal physical and psychological sequale. 46% of respondents reported that they would be willing to try medically supervised psychedelic therapy.
Journal of Clinical Psychiatry and Clinical Neuroscience
May 2022
Cited by 0
Psychedelics as potential catalysts of scientific creativity and insight
This theory-building article (2022) proposes that the dream, hypnagogic and psychedelic states share common features that make them conducive to supporting some aspects of scientific creativity and examines the putative underlying neurophenomenological and cognitive processes involved. The psychedelic state may have the potential to enhance creativity as a result of phenomena like brain hyperconnectivity, meta-cognitive awareness and more.
Drug Science, Policy and Law
May 2022
Cited by 0
The efficacy of psilocybin in the treatment of depression and anxiety: A meta-analysis
This meta-analysis (2022) assessed the effects of psilocybin in the treatment of depression and anxiety. Despite achieving statistical significance in the reduction of depression and anxiety symptoms compared to controls in multiple subgroups, more trials need to be conducted with larger patient populations over longer periods.
Current Psychiatry Research and Reviews
May 2022
Cited by 0
Self-Care Practices with Psychedelics – A Qualitative Study of Users’ Perspectives
Most participants reported using psychedelics with self-care intentions in ceremonial, recreational, or private settings. Self-perception and existential meaningfulness were identified as the main mechanisms of self-care.
Journal of Psychoactive Drugs
May 2022
Cited by 0
Special considerations for evaluating psilocybin-facilitated psychotherapy in vulnerable populations
This report (2022) explores the challenges and opportunities associated with evaluating psilocybin-facilitated psychotherapy (PAP) in vulnerable populations. The authors propose that working with vulnerable populations requires special attention to their context. Recommendations for future research include an emphasis on recruitment strategies, the appropriate communication and assessment of subjective effects, building a therapeutic alliance, multicultural competence, and flexible study designs.
Neuropharmacology
May 2022
Cited by 0
Pharmacokinetics of N,N-Dimethyltrypatamine Fumarate in Humans
This pre-print of a double-blind, placebo-controlled study (2022) evaluated the metabolism and clinical pharmacokinetics (how drugs are processed by the body) of DMT (SPL026) in an ongoing Phase I study with healthy subjects (n=24) by Small Pharma. Participants received escalating doses of SPL026 via a 2-phase intravenous (IV) infusion. SP206 was safe and well-tolerated, and dose-proportional increases in DMT exposure were observed over the range of 9–21.5 mg. For all doses, the median time to peak plasma concentration was ~10 min and the mean elimination half-life was 9–12 min.
Preprints
May 2022
Cited by 0
Acute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis
This meta-analysis assessed the effects of ketamine administration in healthy participants (n=1,041) on several cognitive domains. Deficits in verbal learning/memory were most prominent, whereas response inhibition was the least affected. Negative effects were dependent on infusion dose and plasma level but unaffected by enantiomer type, route of administration, sex or age.
Progress in Neuro-Psychopharmacology and Biological Psychiatry
May 2022
Cited by 0
Lay Perceptions of Treating Mental Illness with Psychedelic Assisted Therapy
This survey study (n=474) assessed participants' perception, potential usage, and recommendations for psychedelic drugs being used as a treatment for mental illnesses. Results show that participants were not open to their personal usage of psychedelics but were more open to recommending psychedelic therapy to their loved ones.
Modern Psychological Studies
May 2022
Hallucinogenic Persisting Perception Disorder: A Case Series and Review of the Literature
This case series includes patients (n=13) with hallucinogen persisting perception disorder (HPPD) and reviews the literature on HPPD. The most common symptoms in patients were visual snow, floaters, palinopsia, photophobia and nyctalopia while symptoms in the literature included visual hallucinations altered motion perception, palinopsia, tracers and colour enhancement. The authors draw parallels between HPPD and Visual Snow Syndrome (VSS), suggesting that the DSM-V criteria for HPPD should be revised to include additional symptoms.
Academic Psychiatry
May 2022
Socio-psychedelic imaginaries: envisioning and building legal psychedelic worlds in the United States
This paper (2022) explores the concept of American socio-psychedelics imaginaries i.e., collective visions articulated and enacted to reintegrate psychedelics legally and responsibly into society. Four imaginaries are discussed including biomedicalization, decriminalization, legalization and sacramental imaginaries. These imaginaries diverge and converge around several politics: politics of access, politics of responsibility, politics of naming, politics of assimilation and social change, and politics of epistemic credibility.
European Journal of Futures Research
April 2022
Characterizing thalamocortical (dys)connectivity following d-amphetamine, LSD, and MDMA administration
This neuroimaging study (n=28) investigated the effects of LSD, d-amphetamine and MDMA on thalamocortical intrinsic functional connectivity (iFC). Each substance elicited auditory-sensorimotor-thalamic-hyperconnectivity compared to placebo, despite predominantly distinct pharmacological actions and subjective effects. LSD produced salience (SAL) hyperactivity whereas MDMA and amphetamine produced hypoconnectivity with SAL. This range of activity is similar to that seen in patients with psychotic disorders.
Biological Psychiatry
April 2022
Cited by 0
Phenomenology and Content of the Inhaled N, N-Dimethyltryptamine (N, N-DMT) Experience
This study (2022) analysed 3,778 DMT experiences posted on the r/DMT Reddit to better understand the phenomenology of the DMT experience. Common themes that were identified include physical and somatic experiences, content of visualizations and imagery, entity encounters, structural characteristics, scenery of the “DMT world, emotional responses, and more.
Research Square
April 2022
Cited by 0
Past-Year Hallucinogen Use in Relation to Psychological Distress, Depression, and Suicidality among US Adults
This study used a sample from the U.S. National Survey on Drug Use and Health (n=241,675) to assess if past-year psychedelic use is associated with reporting past-year serious psychological distress (SPD), major depressive episode (MDE), and suicidality. LSD was associated with an increased likelihood of MDE and suicidal thinking. MDMA use was associated with a decreased likelihood of SPD and suicidal thinking.
Academic Psychiatry
April 2022
Cited by 0
Naturalistic use of psychedelics is related to emotional reactivity and self-consciousness: The mediating role of ego-dissolution and mystical experiences
This survey (n=1,661) found that a higher number of lifetime uses of psychedelics predicted greater positive and lower negative emotional reactivity while measures of self-consciousness predicted greater reflection and internal state awareness, reduced rumination tendency and public self-consciousness. The intensity of past mystical and ego-dissolution experiences mediated almost all the observed relationships between the lifetime number of psychedelic uses and psychological variables.
Journal of Psychopharmacology
April 2022
Cited by 0
The Effects of Psilocybin in Adults with Major Depressive Disorder and The General Population
This review (2022) explored results from neuroimaging studies with psilocybin. In studies with depressed patients, a decrease in amygdala activity and a reduction in depressive symptoms was observed while in healthy participants, changes in functional connectivity and activation of prefrontal limbic structures, specifically the ventral medial prefrontal cortex and amygdala were observed.
Psychiatry Research
April 2022
Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex
This study (2022) applied a non-linear dimensionality reduction technique previously used to map hierarchical connectivity gradients to assess cortical organization in the LSD and psilocybin state from two previously published pharmacological resting-state fMRI datasets. The principal gradient of cortical connectivity was significantly flattened under both drugs relative to their respective placebo conditions. This study is the first to show that macroscale connectivity gradients are sensitive to acute pharmacological manipulation.
NeuroImage
April 2022
Cited by 0
Differences in personality, cognitive abilities, illicit drug use, and white matter structural integrity between hallucinogen users and matched controls
This pre-print (n=106) investigated the association between hallucinogen use, macroscale brain structure, personality, cognitive ability, and illicit drug use in a naturalistic sample. Hallucinogen users scored higher on measures of openness to new experiences, and cognitive ability, and had a greater density of structural connectivity in white matter tracts that are thought to support cognition, emotion, and creativity.
Research Square
April 2022
Cited by 0
Evaluation of Individual Items of the Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS) in Adults with Treatment-Resistant Depression Treated with Esketamine Nasal Spray Combined with a New Oral Antidepressant
This posthoc analysis of the TRANSFORM-2 trial assessed the effects of esketamine plus an oral antidepressant (AD) using the Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS). The odds of improving in those treated with esketamine plus AD were at least two times greater than with placebo plus AD.
CNS Drugs
April 2022
Cited by 0
New Insights into the Chemical Composition of Ayahuasca
This chemistry study (2022) used nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) to study the composition of ayahuasca samples. For the first time, fructose was detected as a major component of the samples, while harmine was found to be present in the solids suspended in the beverage.
ACS Omega
April 2022
Cited by 0
Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders
This study (2022) examines the group therapy model used in MDMA and LSD therapy in private practice in Switzerland. The majority of patients suffered from PTSD with psychedelic therapy addressing symptoms like regulation of emotions and impulses, negative self-perception, alterations in relationships with others, as well as meaning, recall, and processing of traumatic memories. MDMA was most often used in the first phase to enhance motivation to change while LSD was introduced to intensify and deepen the therapeutic process.
Frontiers in Psychiatry
April 2022
Cited by 0
Ketamine for suicidality: an umbrella review
This review (2022) investigated the role of ketamine in suicidal ideation (SI) and behaviours. Of 27 studies that addressed ketamine for SI, only four reported mixed or negative results. Out of nine reviews, esketamine was significantly beneficial in five. Despite the majority of reviews being of critically low quality, the short-term efficacy of ketamine in suicidality was noted in most.
British Journal of Clinical Pharmacology
April 2022
Cited by 0
Prospective association of psychological pain and hopelessness with suicidal thoughts
This study (n=108) used the data from three clinical trials where ketamine was used to treat treatment-resistant depression (TRD) or bipolar disorder (BD) to assess the interaction between hopelessness and psychological pain was associated with future suicidal ideation (SI). Psychological pain and hopelessness were not associated with SI in short-term or long-term analyses yet long-term analyses found that SI was associated with later psychological pain and hopelessness.
Journal of Affective Disorders
April 2022
Cited by 0

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Find all relevant psychedelic research papers in our ever-growing database. Here we cover and connect the latest research and seminal papers. From early open-label psychedelic studies with healthy volunteers to large-scale double-blind placebo-controlled trials.

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