Psychedelic Research Papers

Chronic pain and psychedelics: a review and proposed mechanism of action
This review (2020) investigates the (limited) research on psychedelics for chronic pain and notes the limitations op opioids (and the current epidemic of use).
Regional Anesthesia and Pain Medicine
May 2020
Cited by 55
Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research
In this qualitative study (n=11), people living with chronic pain who self-medicate with psychedelic drugs were interviewed. Participants reported improved pain scores during and after psychedelic experiences across various psychedelics. Positive Reframing and Somatic Presence were identified as playing a role in enhancing well-being. Participants employed other techniques including mindfulness, breathwork, and movement.
Frontiers in Psychiatry
October 2021
Cited by 10
Long-lasting analgesic effect of the psychedelic drug changa: A case report
This case study (n=1) describes the analgesic effects of repeated changa (unspecified amount of DMT) treatment administered to a 57-year-old male doctor who was suffering for 10 years from chronic fatigue and persistent pain due to fibromyalgia.
Journal of Psychedelic Studies
February 2019
Cited by 4
Knowledge, Perceptions, and Use of Psychedelics among Individuals with Fibromyalgia
This survey study (n=354) sought to characterize the knowledge, perceptions and past use of psychedelics among people with fibromyalgia (FM). It was found that 29.9% of respondents reported past use of a psychedelic, and perceptions of benefit from use were generally neutral (59.4%) or positive (36.8%). Less than 3% reported that using psychedelics negatively impacted their overall health or pain symptoms. 11 out of 12 patients using psychedelics specifically to treat pain reported improvements in their symptoms.
Journal of Psychoactive Drugs
January 2022
Cited by 2
Potential analgesic effects of psychedelics on select chronic pain conditions: A survey study
This survey study (n=170) aimed to understand the effectiveness of classical psychedelics in treating chronic pain conditions compared to conventional treatments. The analysis focused on five specific conditions: fibromyalgia, arthritis, migraine, tension-type headache, and sciatica. Results showed that, except for sciatica, participants reported better pain relief using psychedelics than with conventional medication. Specifically, full psychedelic doses outperformed conventional treatments, while microdoses provided significantly better relief for migraines and comparable relief for the other three conditions.
European Journal of Pain
August 2023
Cited by 0

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Find all relevant psychedelic research papers in our ever-growing database. Here we cover and connect the latest research and seminal papers. From early open-label psychedelic studies with healthy volunteers to large-scale double-blind, placebo-controlled trials.

We have not only indexed over 2000 papers but have added additional contexts such as type of study, a compound studied, which paper it’s related to, the trial associated with a study, and over 30 more variables.

More coverage of psychedelic research can be found on our Research page.