Homeostasis Therapeutics

Homeostasis Therapeutics is a pioneering company dedicated to revolutionizing the treatment of anorexia nervosa. Founded by the parents of a young woman who triumphed over a 15-year battle with the illness, the company is driven by a deep understanding of the devastating impact of anorexia nervosa and a commitment to finding a cure. Their mission is to offer an evidence-based, sequential treatment approach that addresses both the metabolic and psychiatric aspects of this complex disorder.

A Novel Treatment Approach

At the core of Homeostasis Therapeutics’ approach lies a two-pronged strategy:

• Ketogenic Diet: Recognizing the potential role of metabolic disturbances in anorexia nervosa, the treatment begins with a modified ketogenic diet. This high-fat, low-carbohydrate dietary plan aims to induce ketosis, shifting the brain’s primary energy source from glucose to ketones. This metabolic shift is believed to impact neurotransmitters and neuropeptides associated with anorexia nervosa, potentially alleviating core symptoms.
• Ketamine Infusions: Following the ketogenic diet, patients undergo a series of intravenous ketamine infusions. Ketamine, known for its rapid-acting antidepressant properties, targets the psychiatric aspects of anorexia nervosa, such as anxiety, obsessive-compulsive behaviors, and depression.

Evidence-Based and Patient-Centered

Homeostasis Therapeutics’ treatment protocol is grounded in scientific research and driven by a deep empathy for patients and their families. The company draws upon evidence from rodent studies, ketamine research, and successful case studies, including the remarkable recovery of the founders’ daughter, Caroline. A five-person clinical trial further demonstrated the potential of this approach, with several patients experiencing significant improvement and sustained remission.

Looking Ahead: Expanding Access and Impact

Homeostasis Therapeutics is actively working to advance their mission and make this innovative treatment accessible to a wider population:

• Larger Clinical Trial: In collaboration with the University of California, San Diego, the company is initiating a larger, randomized clinical trial to further evaluate the efficacy and safety of their treatment protocol.
• Funding and Commercialization: Homeostasis Therapeutics is actively seeking funding to support ongoing research and development efforts, with the ultimate goal of making this life-changing treatment commercially available.