Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

This interventional trial (n=600) will evaluate whether cognitive training can enhance or extend the rapid antidepressant effects of ketamine in patients already receiving ketamine treatment as part of their clinical care.

Conducted by the University of Pittsburgh, this study will involve web-based cognitive training sessions, designed to prime the brain for helpful forms of learning, with the aim of treating depression more efficiently. The trial will compare the effects of cognitive training with sham training, assessing outcomes such as depression severity, hopelessness, and cognitive function over a 12-month period.

The study is expected to run from November 2024 to June 2030.

Trial Details

In a sample of patients already receiving ketamine treatment as part of their clinical care, this project seeks to test whether we can enhance and/or extend ketamine's rapid effects by introducing helpful information delivered by a computer-based cognitive training protocol. This work could ultimately lead to the ability to treat depression more efficiently and with broader dissemination by rapidly priming the brain for helpful forms of learning.

Trial Number NCT06526078

Data attribution

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