Research Study for Major Depressive Disorder: Investigation of Glutamate Medications

This study is examining the safety and effectiveness of two medications, ketamine and riluzole, in treating patients with treatment resistant major depressive disorder. This study will also examine the effectiveness of an FDA approved drug called lamotrigine in decreasing the potential side effects associated with ketamine.

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Status Completed
Start date 12 January 2006
End date 09 January 2008
Chance of happening 100%
Phase Phase IV
Design Blinded
Type Interventional
Generation First
Participants 26
Sex All
Age 21- 70
Therapy No

Trial Details

This research proposal will investigate a glutamate-modulating agent, riluzole, in treatment-resistant patients who exhibit an acute, sustained response to a single dose of intravenous (IV) racemic ketamine. Fifty ketamine-responders will be randomized to riluzole or placebo in a 4-week, randomized, double-blind, continuation-phase study.

NCT Number NCT00419003

Sponsors & Collaborators

Baylor College of Medicine
This company doesn't have a full profile yet, it is linked to a clinical trial.

National Alliance for Research on Schizophrenia and Depression
This company doesn't have a full profile yet, it is linked to a clinical trial.

National Center for Research Resources
This company doesn't have a full profile yet, it is linked to a clinical trial.

Measures Used

Montgomery-Asberg Depression Rating Scale
A ten-item diagnostic questionnaire used to measure the severity of depressive symptoms in patients with mood disorders.

Data attribution

A large set of the trials in our database are sourced from ClinicalTrials.gov (CTG). We have modified these post to display the information in a more clear format or to correct spelling mistakes. Our database in actively updated and may show a different status (e.g. completed) if we have knowledge of this update (e.g. a published paper on the study) which isn't reflected yet on CTG. If a trial is not sourced from CTG, this is indicated on this page and you can follow the link to the alternative source of information.
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